1,1,1,3,3,3-hexafluoro-2-propanol as a reusable media: Green and catalyst-free synthesis of pyrano[2,3-d]pyrimidine scaffolds

A safe method of producing pyrano[2,3-d]pyrimidine scaffolds without the need for a catalyst is shown, utilizing the concepts of green chemistry. This is achieved by employing polyfluorinated alcohol as a reusable medium and mixing barbituric acid/1,3-dimethylbarbituric acid, malononitrile and aryl aldehydes in an environmentally friendly manner. This environmentally friendly method uses one pot, readily accessible, low-cost reaction media, safe reaction conditions, no requirement for column chromatography for separation and effective use of resources. Furthermore, green 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) did not require significant modifications and remained stable for four reuses. This is highly helpful in satisfying industrial demands and resolving environmental issues.

Graphical abstract

Our study shows that 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is used as a reusable medium to synthesize pyrano[2,3-d]pyrimidine frameworks without the need for a catalyst. This eco-friendly, cost-effective and straightforward solution has several benefits. It employs readily accessible materials, reduces the need for costly and dangerous chemicals, saves time and yields high-quality results.