潜力不确定的克隆造血（CHIP）：淋巴瘤的潜在因素。

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2025-02-01 DOI:10.1016/j.critrevonc.2024.104589

QingQing Luo , LiLi Zhou , DaYa Luo , Li Yu

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引用次数: 0

摘要

克隆造血（Clonal hematopoiesis， CH）通常是指造血干细胞（hematopoitic stem cells, hsc）因基因突变而克隆扩增，是多种疾病的致病基础。克隆性造血不确定电位（CHIP）是CH的一种亚型，是髓系恶性肿瘤和心血管疾病的重要危险因素，越来越受到人们的关注。然而，最近的研究揭示了以前被忽视的CHIP和淋巴瘤之间的联系。本文综述了CHIP与淋巴瘤的关系，重点从实验室研究和临床观察两方面阐述了TET2和dnmt3a介导的CHIP在淋巴瘤中的作用和机制。此外，我们还探讨了靶向CHIP基因和淋巴瘤炎症途径的治疗意义。我们的研究结果强调了CHIP对淋巴瘤发展的多方面影响，并为CHIP介导的淋巴瘤的治疗干预提供了一条有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma

Clonal hematopoiesis (CH) typically refers to the clonal expansion of hematopoietic stem cells (HSCs) due to genetic mutations, serving as the pathogenic basis for various diseases. Clonal hematopoiesis of indeterminate potential (CHIP) is a subtype of CH, emerging as a significant risk factor for myeloid malignancies and cardiovascular diseases, which has attracted increasing attention. However, recent research has unveiled previously overlooked links between CHIP and lymphoma. This paper reviews the relationship between CHIP and lymphoma, focusing on the role and mechanism of TET2 and DNMT3A-mediated CHIP in lymphoma from the perspective of laboratory research and clinical observation. Additionally, we explore the therapeutic implications of targeting CHIP genes and inflammatory pathways in lymphoma. Our findings underscore the multifaceted influence of CHIP on lymphoma development and provide a promising avenue for therapeutic interventions in CHIP mediated lymphoma.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.