术前骨骼肌质量联合评估对胃癌根治性胃切除术患者的肿瘤学影响。

IF 1.6 4区 医学 Q2 SURGERY
Surgery Today Pub Date : 2025-07-01 Epub Date: 2024-12-13 DOI:10.1007/s00595-024-02978-9
Ryota Matsui, Manabu Ohashi, Motonari Ri, Rie Makuuchi, Tomoyuki Irino, Masaru Hayami, Takeshi Sano, Souya Nunobe
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引用次数: 0

摘要

目的:我们采用骨骼肌质量指数(SMI)和腰肌指数(PMI)联合评估骨骼肌质量,以评估其与胃癌根治性胃切除术后患者总生存期(OS)的关系。方法:回顾性分析2010年4月至2016年4月间接受根治性胃切除术的pi - iii期胃癌患者骨骼肌质量的计算机断层扫描记录。然后,我们将OS作为主要结局进行比较,根据患者的SMI或PMI对患者进行分层,并使用多变量分析调查预后因素。结果:中位随访时间为62个月。550例患者中,正常组262例(47.6%),单低组194例(35.3%),双低组94例(17.1%)。SMI和PMI双低的患者OS最差(P = 0.018)。多因素分析显示,双低指数是不良OS的独立预后因素(风险比为1.808;95%置信区间1.009-3.238;p = 0.046)。结论:本研究显示,基于SMI和PMI联合评价骨骼肌质量可以预测胃癌根治性胃切除术后患者的生存结局,低SMI和低PMI共存与最差生存相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oncological impact of the preoperative combined assessment of skeletal muscle mass for patients undergoing curative gastrectomy for gastric cancer.

Purpose: We performed a combined assessment of skeletal muscle mass using the skeletal muscle mass index (SMI) and the psoas muscle index (PMI) to evaluate their association with the overall survival (OS) of gastric cancer patients after curative gastrectomy.

Methods: We analyzed, retrospectively, the computed tomography records of skeletal muscle mass of patients who underwent radical gastrectomy for pStage I-III gastric cancer between April, 2010 and April, 2016. We then compared OS as the primary outcome, stratifying patients according to their SMI or PMI, and investigated prognostic factors using multivariate analyses.

Results: The median follow-up duration was 62 months. Of the 550 patients analyzed, 262 (47.6%), 194 (35.3%), and 94 (17.1%) were classified into normal, single-low, and double-low SMI and PMI groups, respectively. Patients with double-low SMI and PMI had the poorest OS (P = 0.018). Multivariate analysis revealed that double-low indices were an independent prognostic factor for poor OS (hazard ratio, 1.808; 95% confidence interval 1.009-3.238; P = 0.046).

Conclusions: This study revealed that evaluation of skeletal muscle mass based on the combined SMI and PMI can predict the survival outcomes of patients after curative gastrectomy for gastric cancer, and that the coexistence of a low-SMI and low-PMI was associated with the poorest survival.

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来源期刊
Surgery Today
Surgery Today 医学-外科
CiteScore
4.90
自引率
4.00%
发文量
208
审稿时长
1 months
期刊介绍: Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.
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