Giorgia T Maniscalco, Alessandro Dinoto, Maria C Foglia, Maria E Di Battista, Ornella Moreggia, Daniele Di Giulio Cesare, Michela Williams, Francesca W Rossi, Sara Carta, Vanessa Chiodega, Sergio Ferrari, Assunta Viola, Amato de Paulis, Vincenzo Andreone, Sara Mariotto
{"title":"MOGAD 患者的 Epstein-Barr 病毒感染。","authors":"Giorgia T Maniscalco, Alessandro Dinoto, Maria C Foglia, Maria E Di Battista, Ornella Moreggia, Daniele Di Giulio Cesare, Michela Williams, Francesca W Rossi, Sara Carta, Vanessa Chiodega, Sergio Ferrari, Assunta Viola, Amato de Paulis, Vincenzo Andreone, Sara Mariotto","doi":"10.1177/13524585241298065","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Epstein-Barr virus (EBV) infection increases the risk of having multiple sclerosis (MS). Data on adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are lacking.</p><p><strong>Objective: </strong>To compare EBV serological status in MOGAD versus MS.</p><p><strong>Methods: </strong>We measured antibodies to Epstein-Barr nuclear antigen (EBNA-1) and viral capsid antigen (VCA) antigens in 129 patients (MS = 74, MOGAD = 55) by chemiluminescence immunoassays.</p><p><strong>Results: </strong>VCA-IgG were detected in 97.3% of MS and 96.4% of MOGAD cases, while EBNA-1-IgG in 97.3% of MS and 80% of MOGAD (<i>p</i> = 0.001). EBNA-1 (<i>p</i> < 0.001) and VCA (<i>p</i> = 0.03) antibodies levels were higher in MS patients.</p><p><strong>Conclusion: </strong>EBV antibodies are higher in MS versus MOGAD, suggesting a possible different role of EBV in the pathogenesis of the two conditions.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"117-120"},"PeriodicalIF":4.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epstein-Barr virus infection in patients with MOGAD.\",\"authors\":\"Giorgia T Maniscalco, Alessandro Dinoto, Maria C Foglia, Maria E Di Battista, Ornella Moreggia, Daniele Di Giulio Cesare, Michela Williams, Francesca W Rossi, Sara Carta, Vanessa Chiodega, Sergio Ferrari, Assunta Viola, Amato de Paulis, Vincenzo Andreone, Sara Mariotto\",\"doi\":\"10.1177/13524585241298065\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Epstein-Barr virus (EBV) infection increases the risk of having multiple sclerosis (MS). Data on adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are lacking.</p><p><strong>Objective: </strong>To compare EBV serological status in MOGAD versus MS.</p><p><strong>Methods: </strong>We measured antibodies to Epstein-Barr nuclear antigen (EBNA-1) and viral capsid antigen (VCA) antigens in 129 patients (MS = 74, MOGAD = 55) by chemiluminescence immunoassays.</p><p><strong>Results: </strong>VCA-IgG were detected in 97.3% of MS and 96.4% of MOGAD cases, while EBNA-1-IgG in 97.3% of MS and 80% of MOGAD (<i>p</i> = 0.001). EBNA-1 (<i>p</i> < 0.001) and VCA (<i>p</i> = 0.03) antibodies levels were higher in MS patients.</p><p><strong>Conclusion: </strong>EBV antibodies are higher in MS versus MOGAD, suggesting a possible different role of EBV in the pathogenesis of the two conditions.</p>\",\"PeriodicalId\":18874,\"journal\":{\"name\":\"Multiple Sclerosis Journal\",\"volume\":\" \",\"pages\":\"117-120\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple Sclerosis Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13524585241298065\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585241298065","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Epstein-Barr virus infection in patients with MOGAD.
Background: Epstein-Barr virus (EBV) infection increases the risk of having multiple sclerosis (MS). Data on adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are lacking.
Objective: To compare EBV serological status in MOGAD versus MS.
Methods: We measured antibodies to Epstein-Barr nuclear antigen (EBNA-1) and viral capsid antigen (VCA) antigens in 129 patients (MS = 74, MOGAD = 55) by chemiluminescence immunoassays.
Results: VCA-IgG were detected in 97.3% of MS and 96.4% of MOGAD cases, while EBNA-1-IgG in 97.3% of MS and 80% of MOGAD (p = 0.001). EBNA-1 (p < 0.001) and VCA (p = 0.03) antibodies levels were higher in MS patients.
Conclusion: EBV antibodies are higher in MS versus MOGAD, suggesting a possible different role of EBV in the pathogenesis of the two conditions.
期刊介绍：
Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system.
The journal for your research in the following areas:
* __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics
* __Epidemology and genetics:__ genetics epigenetics, epidemiology
* __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures
* __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management
Print ISSN: 1352-4585
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
