Dania M Rodriguez, Zachary J Madewell, Jomil M Torres, Aidsa Rivera, Joshua M Wong, Gilberto A Santiago, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Melissa Marzan-Rodriguez, Laura E Adams
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During 2023-2024, the median age of dengue cases increased to 26 years (95% CI = 25-27 years) compared with that during 2020-2022 (17 years; 95% CI = 17-18 years) and 2010-2019 (19 years; 95% CI = 19-19 years). After >10 years of DENV-1 predominance, the proportions of DENV serotypes 2 (DENV-2) and 3 (DENV-3) increased significantly during 2023-2024, with DENV-3 replacing DENV-1 as the predominant serotype. In addition, the proportion of dengue patients who were hospitalized increased from 35.7% (2010-2019) to 53.5% (2023-2024). The current dengue outbreak in Puerto Rico marks a shift in serotype predominance to DENV-3 and increasing percentages of cases in older age groups (61.7% in adults aged ≥20 years), although a high proportion of cases still occur among adolescents aged 10-19 years (29.5%). The current dengue outbreak also has a higher rate of hospitalizations than those in previous years. 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引用次数: 0
摘要
登革热是一种蚊媒病毒性疾病，可引起急性发热性疾病、严重疾病或死亡。在世界范围内，登革热病例的数量正在增加。2010-2013年波多黎各最后一次登革热疫情期间，血清型1型登革热病毒（DENV-1）占主导地位，10-19岁青少年和青壮年中病例所占比例最大。2010年1月1日至2024年11月4日的登革热病例数据来自波多黎各卫生部。采用双变量分析评估2010-2019年、2020-2022年和2023-2024年三个时期患者年龄、DENV血清型和住院情况的病例分布。2023-2024年期间，登革热病例的中位年龄增加到26岁（95% CI = 25-27岁），而2020-2022年期间(17岁；95% CI = 17-18年)和2010-2019年(19年；95% CI = 19-19年)。经过10年DENV-1的优势，DENV 2血清型（DENV-2）和3血清型（DENV-3）的比例在2023-2024年间显著增加，DENV-3取代DENV-1成为主要血清型。此外，登革热住院患者比例从35.7%（2010-2019年）增加到53.5%（2023-2024年）。波多黎各目前的登革热疫情标志着血清型优势向DENV-3型转变，老年群体中的病例百分比增加（20岁以上成年人中61.7%），尽管10-19岁青少年中仍有很大比例的病例（29.5%）。目前的登革热疫情的住院率也高于前几年。了解登革热流行病学的变化对于指导登革热控制的公共卫生战略至关重要，包括临床管理、监测和卫生保健系统复原力，以及公众宣传和教育。
Dengue is a mosquitoborne viral illness that can cause acute febrile illness, severe disease, or death. Worldwide, the number of dengue cases is increasing. During the last dengue outbreaks in Puerto Rico throughout 2010-2013, dengue virus (DENV) serotype 1 (DENV-1) predominated, and the largest proportion of cases occurred among adolescents and young adults aged 10-19 years. Dengue case data from January 1, 2010-November 4, 2024, were obtained from the Puerto Rico Department of Health. Bivariate analyses were conducted to evaluate the distribution of cases by patient age, DENV serotype, and hospitalization status during three periods: 2010-2019, 2020-2022, and 2023-2024. During 2023-2024, the median age of dengue cases increased to 26 years (95% CI = 25-27 years) compared with that during 2020-2022 (17 years; 95% CI = 17-18 years) and 2010-2019 (19 years; 95% CI = 19-19 years). After >10 years of DENV-1 predominance, the proportions of DENV serotypes 2 (DENV-2) and 3 (DENV-3) increased significantly during 2023-2024, with DENV-3 replacing DENV-1 as the predominant serotype. In addition, the proportion of dengue patients who were hospitalized increased from 35.7% (2010-2019) to 53.5% (2023-2024). The current dengue outbreak in Puerto Rico marks a shift in serotype predominance to DENV-3 and increasing percentages of cases in older age groups (61.7% in adults aged ≥20 years), although a high proportion of cases still occur among adolescents aged 10-19 years (29.5%). The current dengue outbreak also has a higher rate of hospitalizations than those in previous years. Understanding the changing epidemiology of dengue is crucial to guiding public health strategies for dengue control, including clinical management, surveillance and health care system resilience, and public outreach and education.
期刊介绍：
The Morbidity and Mortality Weekly Report (MMWR ) series is prepared by the Centers for Disease Control and Prevention (CDC).
Often called “the voice of CDC,” the MMWR series is the agency’s primary vehicle for scientific publication of timely, reliable, authoritative, accurate, objective, and useful public health information and recommendations.
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