家庭样本中双相情感障碍的遗传性、表型和遗传相关性的维度和分类模型。

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Alejandro Arbona-Lampaya, Heejong Sung, Alexander D'Amico, Emma E M Knowles, Emily K Besançon, Ally Freifeld, Ley Lacbawan, Fabiana Lopes, Layla Kassem, Antonio E Nardi, Francis J McMahon
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引用次数: 0

摘要

背景:躁郁症(BD)的症状范围很广,不同亲属间的症状也不尽相同,这使人们对分类疾病模型产生了怀疑。为了解决这一不确定性,我们在一个家族样本中调查了躁郁症分类模型和维度模型之间的遗传率和遗传关系:这项回顾性研究纳入了南北美洲阿米什-门诺派躁狂症遗传学(AMBiGen)研究的参与者(n = 397 名女性,n = 329 名男性,平均年龄 47 岁),这些参与者通过结构化精神病学访谈被归类为心境障碍诊断("狭义 "或 "广义"),并完成了心境障碍问卷(MDQ),该问卷用于评估一生中的躁狂症状史和相关损害。通过主成分分析法(PCA)对 MDQ 的各个维度进行了分析。利用 SOLAR-ECLIPSE 对 432 名基因分型参与者的分类诊断和 MDQ 维度之间的遗传性和遗传重叠进行了估计:结果:与其他情绪障碍患者(26%)或无情绪障碍患者(9%)相比,诊断为 BD 的患者(n = 124)认可的 MDQ 项目更多(61%)。PCA表明MDQ由三部分组成,可捕捉60%的方差。MDQ及其主成分的遗传率显著但不高(20-30%,p 局限性:通过患有 BD 的原发性患者招募样本导致样本中 BD 患病率增加,从而限制了样本的普遍性。无法获得的遗传数据减少了某些分析的样本量:研究结果支持BD的维度模型和分类模型之间的遗传连续性,并表明MDQ是BD遗传研究的有用表型测量指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heritability, phenotypic, and genetic correlations across dimensional and categorical models of bipolar disorder in a family sample.

Background: Bipolar disorder (BD) presents with a wide range of symptoms that vary among relatives, casting doubt on categorical illness models. To address this uncertainty, we investigated the heritability and genetic relationships between categorical and dimensional models of BD in a family sample.

Methods: This retrospective study included participants (n = 397 Females, n = 329 Males, mean age 47 yr) in the Amish-Mennonite Bipolar Genetics (AMBiGen) study from North and South America that were assigned categorical mood disorder diagnoses ("narrow" or "broad") by structured psychiatric interview and completed the Mood Disorder Questionnaire (MDQ), which assesses lifetime history of manic symptoms and associated impairment. MDQ-dimensions were analyzed by Principal Component Analysis (PCA). Heritability and genetic overlaps between categorical diagnoses and MDQ-dimensions were estimated with SOLAR-ECLIPSE within 432 genotyped participants.

Results: Individuals diagnosed with BD (n = 124) endorsed more MDQ items (61 %) than those with other mood disorders (26 %) or with no mood disorder (9 %), as expected. PCA suggested a three-component model for the MDQ, capturing 60 % of the variance. Heritability of the MDQ and its principal components was significant but modest (20-30 %, p < 0.001). Genetic correlations between MDQ measures and categorical diagnoses (ρG = 0.62-1.0; p < 0.001) were stronger than phenotypic correlations (ρP = 0.11-0.58; p < 0.001).

Limitations: Recruitment through probands with BD resulted in increased prevalence of BD in this sample, limiting generalizability. Unavailable genetic data reduced sample size for some analyses.

Conclusion: Findings support a genetic continuity between dimensional and categorical models of BD and suggest that the MDQ is a useful phenotype measure for genetic studies of BD.

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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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