Xindi Lin, Shaogen Zhong, Mengxing Wang, Yi Mao, Yuhan Wu, Jiayi Lu, Wei Zhong, Di Wu, Jun Ma
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Resting-state images were analyzed using whole-brain correlation techniques and AlphaSim correction to identify brain regional activities and resting-state functional connectivity (RSFC) associated with MDA functional grade scores.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Whole-brain correlation analysis demonstrated that the fractional amplitude of low-frequency fluctuations in the right angular gyrus (AG) exhibited a negative correlation with MDA functional grade scores (<i>r</i><sub>s</sub> = −0.336, <i>p</i> < 0.001), indicating reduced neural activity in this region with MDA dysfunction. 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引用次数: 0
摘要
背景：排尿欲望唤醒（MDA）功能在原发性夜间遗尿（PNE）的发生发展中起关键作用；然而，其神经关联在很大程度上仍未被探索。因此，本研究旨在确定与MDA功能相关的特定脑区域活动。方法：收集2018年7月至2022年11月在上海儿童医疗中心发育与行为儿科学就诊的173名MDA功能分级评分不同的儿童的神经影像学数据。使用全脑相关技术和AlphaSim校正分析静息状态图像，以识别与MDA功能分级评分相关的脑区域活动和静息状态功能连接（RSFC）。结果：全脑相关分析显示，右角回（AG）低频波动的分数幅值与MDA功能分级评分呈负相关（rs = -0.336, p < 0.001），表明该区域的神经活动减少，MDA功能障碍。相反，右侧额叶中回和右侧AG之间的RSFC与MDA功能等级评分呈正相关（rs = 0.274, p < 0.001），表明这些区域的连连接性增加与MDA功能恶化相关。结论：这些发现为MDA功能的神经基础提供了初步的见解。
The Resting-State Activities of the Angular Gyrus and the Micturition Desire-Awakening Function in Children With and Without Enuresis
Background
Micturition desire-awakening (MDA) function plays a pivotal role in the development of primary nocturnal enuresis (PNE); however, its neural correlates remain largely unexplored. Consequently, this study aimed to identify specific brain regional activities associated with MDA function.
Methods
Neuroimaging data were collected from 173 children with varying MDA functional grade scores at the Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, from July 2018 to November 2022. Resting-state images were analyzed using whole-brain correlation techniques and AlphaSim correction to identify brain regional activities and resting-state functional connectivity (RSFC) associated with MDA functional grade scores.
Results
Whole-brain correlation analysis demonstrated that the fractional amplitude of low-frequency fluctuations in the right angular gyrus (AG) exhibited a negative correlation with MDA functional grade scores (rs = −0.336, p < 0.001), indicating reduced neural activity in this region with MDA dysfunction. Conversely, RSFC between the right middle frontal gyrus and the right AG was positively correlated with MDA functional grade scores (rs = 0.274, p < 0.001), suggesting increased connectivity in these areas associated with worse MDA functionality.
Conclusion
These findings provide preliminary insights into the neural underpinnings of MDA functionality.
期刊介绍：
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