2h -氮嘧啶-2,2-二羧酸及其衍生物的合成。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.264

Anastasiya V Agafonova, Mikhail S Novikov, Alexander F Khlebnikov

引用次数: 0

摘要

报道了用fecl2催化3-芳基-5-氯异恶唑-4-羰基氯化物异构化制备3-芳基-2 - h -氮嘧啶-2,2-二羧酸及其酰胺、酯和叠氮化物的方法，并与亲核试剂反应。介绍了制备3-芳基-5-氯异恶唑-4-羰基氯化物的两种方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives.

Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl₂-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by their reaction with nucleophiles are reported. Two approaches to the preparation of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides have been developed.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.