{"title":"基于脉冲振荡法的COPD严重程度新分类：基于中国ECOPD队列的SAIO分级","authors":"Lifei Lu, Qi Wan, Gaoying Tang, Fan Wu, Zhishan Deng, Jieqi Peng, Cuiqiong Dai, Kunning Zhou, Xiaohui Wu, Shuqing Yu, Yongqing Huang, Changli Yang, Shengtang Chen, Pixin Ran, Yumin Zhou","doi":"10.1016/j.arbres.2024.10.005","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Recently, the severities of chronic obstructive pulmonary disease (COPD) can also be assessed by impulse oscillometry (IOS). This study aimed to explore a new classification of severity of COPD based on IOS and associations with acute exacerbations (AE) in patients with COPD.</p><p><strong>Methods: </strong>The data of our study were based on the baseline and 2-year follow-up data of a prospective cohort in China. COPD was defined as post-bronchodilator FEV<sub>1</sub>/FVC <0.70. A new severity classification (staging of airflow obstruction by IOS, SAIO) was evaluated based on IOS parameters (R5, R5-R20, and X5 z-scores). We quantified using the weighted Bangdiwala B for agreement of severities of COPD between IOS parameters and FEV<sub>1</sub>%pred. The differences among SAIO stages were performed in symptom scores and imaging using analysis of covariance, and in the AE using Poisson regression.</p><p><strong>Results: </strong>Overall, 833 patients with COPD were included in this study. The weighted Bangdiwala B of R5, R5-R20, X5 z-scores, and FEV<sub>1</sub>%pred for evaluating agreement of the severities of COPD was 0.68, 0.70 and 0.83, respectively. The SAIO classifications system identified a greater number of patients with stage III-IV. SAIO provided significant discrimination between the stage I and stage III, IV for symptom scores, emphysema, and air trapping. SAIO provided significant discrimination between the stage I and other stages for AE.</p><p><strong>Conclusions: </strong>The SAIO classifications provide discrimination between the stage I and stage III, IV for symptom scores, emphysema, air trapping, and AE, similar to the GOLD classifications.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR1900024643. Registered on 19 July, 2019.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New Classifications of COPD Severity Based on Impulse Oscillometry: A SAIO Grade Base on ECOPD Cohort in China.\",\"authors\":\"Lifei Lu, Qi Wan, Gaoying Tang, Fan Wu, Zhishan Deng, Jieqi Peng, Cuiqiong Dai, Kunning Zhou, Xiaohui Wu, Shuqing Yu, Yongqing Huang, Changli Yang, Shengtang Chen, Pixin Ran, Yumin Zhou\",\"doi\":\"10.1016/j.arbres.2024.10.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Recently, the severities of chronic obstructive pulmonary disease (COPD) can also be assessed by impulse oscillometry (IOS). This study aimed to explore a new classification of severity of COPD based on IOS and associations with acute exacerbations (AE) in patients with COPD.</p><p><strong>Methods: </strong>The data of our study were based on the baseline and 2-year follow-up data of a prospective cohort in China. COPD was defined as post-bronchodilator FEV<sub>1</sub>/FVC <0.70. A new severity classification (staging of airflow obstruction by IOS, SAIO) was evaluated based on IOS parameters (R5, R5-R20, and X5 z-scores). We quantified using the weighted Bangdiwala B for agreement of severities of COPD between IOS parameters and FEV<sub>1</sub>%pred. The differences among SAIO stages were performed in symptom scores and imaging using analysis of covariance, and in the AE using Poisson regression.</p><p><strong>Results: </strong>Overall, 833 patients with COPD were included in this study. The weighted Bangdiwala B of R5, R5-R20, X5 z-scores, and FEV<sub>1</sub>%pred for evaluating agreement of the severities of COPD was 0.68, 0.70 and 0.83, respectively. The SAIO classifications system identified a greater number of patients with stage III-IV. SAIO provided significant discrimination between the stage I and stage III, IV for symptom scores, emphysema, and air trapping. SAIO provided significant discrimination between the stage I and other stages for AE.</p><p><strong>Conclusions: </strong>The SAIO classifications provide discrimination between the stage I and stage III, IV for symptom scores, emphysema, air trapping, and AE, similar to the GOLD classifications.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR1900024643. Registered on 19 July, 2019.</p>\",\"PeriodicalId\":8339,\"journal\":{\"name\":\"Archivos De Bronconeumologia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos De Bronconeumologia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.arbres.2024.10.005\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos De Bronconeumologia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.arbres.2024.10.005","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
New Classifications of COPD Severity Based on Impulse Oscillometry: A SAIO Grade Base on ECOPD Cohort in China.
Background: Recently, the severities of chronic obstructive pulmonary disease (COPD) can also be assessed by impulse oscillometry (IOS). This study aimed to explore a new classification of severity of COPD based on IOS and associations with acute exacerbations (AE) in patients with COPD.
Methods: The data of our study were based on the baseline and 2-year follow-up data of a prospective cohort in China. COPD was defined as post-bronchodilator FEV1/FVC <0.70. A new severity classification (staging of airflow obstruction by IOS, SAIO) was evaluated based on IOS parameters (R5, R5-R20, and X5 z-scores). We quantified using the weighted Bangdiwala B for agreement of severities of COPD between IOS parameters and FEV1%pred. The differences among SAIO stages were performed in symptom scores and imaging using analysis of covariance, and in the AE using Poisson regression.
Results: Overall, 833 patients with COPD were included in this study. The weighted Bangdiwala B of R5, R5-R20, X5 z-scores, and FEV1%pred for evaluating agreement of the severities of COPD was 0.68, 0.70 and 0.83, respectively. The SAIO classifications system identified a greater number of patients with stage III-IV. SAIO provided significant discrimination between the stage I and stage III, IV for symptom scores, emphysema, and air trapping. SAIO provided significant discrimination between the stage I and other stages for AE.
Conclusions: The SAIO classifications provide discrimination between the stage I and stage III, IV for symptom scores, emphysema, air trapping, and AE, similar to the GOLD classifications.
Trial registration: Chinese Clinical Trial Registry, ChiCTR1900024643. Registered on 19 July, 2019.
期刊介绍：
Archivos de Bronconeumologia is a scientific journal that specializes in publishing prospective original research articles focusing on various aspects of respiratory diseases, including epidemiology, pathophysiology, clinical practice, surgery, and basic investigation. Additionally, the journal features other types of articles such as reviews, editorials, special articles of interest to the society and editorial board, scientific letters, letters to the editor, and clinical images. Published monthly, the journal comprises 12 regular issues along with occasional supplements containing articles from different sections.
All manuscripts submitted to the journal undergo rigorous evaluation by the editors and are subjected to expert peer review. The editorial team, led by the Editor and/or an Associate Editor, manages the peer-review process. Archivos de Bronconeumologia is published monthly in English, facilitating broad dissemination of the latest research findings in the field.
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