Germanyl三唑作为CuAAC多样化和化学选择性正交交叉偶联的平台。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.265

John M Halford-McGuff, Thomas M Richardson, Aidan P McKay, Frederik Peschke, Glenn A Burley, Allan J B Watson

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引用次数: 0

摘要

本文报道了通过铜催化叠氮化物-炔环加成（CuAAC）合成锗基三唑。该反应通常产率高，官能团耐受，与复杂分子相容。Ge片段的安装使三唑产物进一步多样化，包括使用双功能硼基/germyl物种的化学选择性过渡金属催化交叉偶联反应。

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Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling.

We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.