- Book学术

发布求助

文献互助智能选刊最新文献

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2024-12-12 DOI:10.1002/cbic.202400774

Zhennan Liu, Yee-Song Law, Ravi Kumar Verma, Yi Ling Goh, Mun Fei Eddy Wong, Barindra Sana, Hao Fan, Ee Lui Ang, Yee Hwee Lim

引用次数: 0

摘要

人工金属酶（ArMs）的开发为将非天然化学反应纳入生物催化提供了一种有效的方法。在此，我们报告了通过将生物素化的锰（沙伦）复合物嵌入链霉亲和素（Sav）变体，组装出基于锰（沙伦）的 ArMs。这些生物杂化催化剂使用市售的腈类和氧转移试剂，催化了烯类的叠氮化反应和苄基 C-H 键的氧化反应，周转次数分别高达 19 次和 146 次。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A Mn(salen)-Based Artificial Metalloenzyme for Nitrene and Oxene Transfer Catalysis.

The development of artificial metalloenzymes (ArMs) offers a potent approach to incorporate non-natural chemical reactions into biocatalysis. Here we report the assembly of Mn(salen)-based ArMs by embedding biotinylated Mn(salen) complexes into streptavidin (Sav) variants. Using commercially available nitrene and oxo transfer reagents, these biohybrid catalysts catalyzed the aziridination of alkenes and oxidation of benzylic C-H bonds with up to 19 and 146 turnover numbers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).