IF 8 1区 医学 Q1 CELL BIOLOGY
Aging Cell Pub Date : 2024-12-12 DOI:10.1111/acel.14447
Yu Li, Jinxin Qi, Linhong Guo, Xian Jiang, Gu He
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引用次数: 0

摘要

细胞内的细胞器平衡和串联已成为细胞生存和功能的重要调节和决定因素。为了应对各种刺激,细胞可激活细胞器质量控制系统(QCS)以维持平衡。大量研究表明,细胞质量控制系统的功能障碍可导致各种与衰老相关的疾病,如神经退行性疾病、肺病、心脏代谢疾病和癌症。然而,人们对 QCS 之间的相互作用及其在这些疾病中的潜在作用还知之甚少。在这篇综述中,我们概述了目前有关 QCS 及其相互影响的研究结果,包括线粒体、内质网、高尔基体、核糖体、过氧化物酶体、脂滴和溶酶体,以及这些细胞器之间导致衰老相关疾病发生和发展的异常相互作用。此外,还讨论了基于这些质量控制相互作用的潜在治疗方法。我们的观点有助于加深对质量控制和衰老及衰老相关疾病病理基础调控网络的了解,从而为开发新型治疗靶点铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Organellar quality control crosstalk in aging-related disease: Innovation to pave the way.

Organellar homeostasis and crosstalks within a cell have emerged as essential regulatory and determining factors for the survival and functions of cells. In response to various stimuli, cells can activate the organellar quality control systems (QCS) to maintain homeostasis. Numerous studies have demonstrated that dysfunction of QCS can lead to various aging-related diseases such as neurodegenerative, pulmonary, cardiometabolic diseases and cancers. However, the interplay between QCS and their potential role in these diseases are poorly understood. In this review, we present an overview of the current findings of QCS and their crosstalk, encompassing mitochondria, endoplasmic reticulum, Golgi apparatus, ribosomes, peroxisomes, lipid droplets, and lysosomes as well as the aberrant interplays among these organelles that contributes to the onset and progression of aging-related disorders. Furthermore, potential therapeutic approaches based on these quality control interactions are discussed. Our perspectives can enhance insights into the regulatory networks underlying QCS and the pathology of aging and aging-related diseases, which may pave the way for the development of novel therapeutic targets.

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来源期刊
Aging Cell
Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology
自引率
2.60%
发文量
212
期刊介绍: Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.
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