镧介导丁腈大体积叔烷基胺的便捷合成

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-12-13 DOI:10.1039/d4cc05831c

Emily K. Burke , Katherine N. Robertson , Alexander W. H. Speed

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引用次数: 0

摘要

叔烷基胺可以在市售的氯化镧-氯化锂络合物溶液中通过双加乙基或丙基格氏试剂一步合成。该反应在多种苯腈上进行，几种杂环腈和烷基腈也可作为合适的底物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Convenient lanthanum-mediated synthesis of bulky tert-alkyl amines from nitriles†

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Convenient lanthanum-mediated synthesis of bulky tert-alkyl amines from nitriles†

Tert-alkyl amines can be conveniently prepared in one step from nitriles by a double addition of ethyl or propyl Grignard reagent mediated by a commercially available lanthanum chloride–lithium chloride complex solution. The reaction operates on a variety of benzonitriles, with several heterocyclic nitriles and an alkyl nitrile also being suitable substrates.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.