[马德里共同体接触硫唑嘌呤-别嘌呤醇相互作用的患者的医疗-药物干预]。

IF 0.9 Q4 PRIMARY HEALTH CARE
J.M. Pinar Manzanet , J.M. Izquierdo Palomares , E. Prieto Utiel , L. Escudero Crujera , M.E. Trillo Gallo , I. Santaolalla García , A. Blázquez Valerón , B.M. Escudero Vilaplana , A.I. Villimar Rodríguez , M. Cortijo Caballero , Á. Mataix Sanjuan , J.M. San Román Montero
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引用次数: 0

摘要

目的:评价医学-药物干预策略对马德里社区(CM)硫唑嘌呤-别嘌呤醇(AZA-ALO)相互作用暴露患者的影响。材料/方法:多中心回顾性观察研究。我们回顾了在医疗保健环境中进行干预后产生的数据库,其中初级保健药剂师(PCP)审查有安全风险的患者的治疗,当发生事故时,他们(通过电话和/或电子邮件)联系他们的家庭医生(FP)以寻求可能的解决方案。研究人群:根据国家卫生系统(NHS)的处方账单数据,在2022年4月至6月期间,在初级保健中有活跃临床病史的CM患者已经分配了两种药物(AZA-ALO)。主要变量:两种药物的抑制或剂量调整。结果:对49例患者进行了分析。平均年龄:65.65±11.67岁。男性;77.6%。8834例患者从药店停药硫唑嘌呤(28724包),89297例患者从药店停药别嘌呤醇(141188包),存在风险的患者比例极低(结论:药师和医生协调干预有效,很大比例的患者修改了处方,降低了毒性风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intervención médico-farmacéutica sobre pacientes expuestos a la interacción azatioprina-alopurinol en la Comunidad de Madrid

Objective

To evaluate the impact of a medical-pharmaceutical intervention strategy on patients exposed to azathioprine-allopurinol (AZA-ALO) interaction in the Community of Madrid (CM).

Material/methods

Multicentre retrospective observational study. We reviewed the database generated after an intervention carried out in the healthcare context in which Primary Care Pharmacists (PCP) review the treatment of patients with safety risks and, when there are incidents, they contact (by telephone and/or e-mail) their Family Physicians (FP) for possible resolution.

Study population

CM patients with an active clinical history in Primary Care who have been dispensed both medications (AZA-ALO) in the period April-June 2022 according to prescription billing data from the National Health System (NHS).
Main variable: suppression or dose adjustment of either of the two drugs.

Results

Forty-nine patients were analysed. Mean age: 65.65 ± 11.67 years. Males; 77.6%. 8,834 patients withdrew azathioprine (28,724 packs) and 89,297 withdrew allopurinol (141,188 packs) from pharmacies, with a very low prevalence of patients at risk (<1%).
The prescription was modified in 32 patients (65.31%-IC95%: 51.98%-78.63%), with allopurinol being discontinued in 65.62% and, with regard to azathioprine, the dose was reduced by 18.75% and discontinued in 9.37%.
Analytical alterations compatible with adverse effects due to the interaction were recorded in 28 patients (57.1%-IC95%: 43.29%-71%), including anaemia (39.3%) and leukopenia/neutropenia (25%).

Conclusions

Coordinated intervention between pharmacists and physicians was effective, resulting in prescription modification in a significant percentage of patients, which reduced the risk of toxicity.
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来源期刊
Medicina de Familia-SEMERGEN
Medicina de Familia-SEMERGEN PRIMARY HEALTH CARE-
CiteScore
1.40
自引率
18.20%
发文量
83
审稿时长
39 days
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