远端和多样化的三级和四级立体中心易于构建。

IF 9.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2024-12-17 Epub Date: 2024-12-12 DOI:10.1073/pnas.2408541121

Chong Liu, Robbie Ge, Jun Chen, Hongmei Guo, Tyler A Bartholome, Debabrata Maiti, Haibo Ge

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引用次数: 0

摘要

探索新的手性候选药物是合成化学家沉浸式努力的动力。以高效的方式实现骨架结构和手性多样性是化学社会的一个重大目标。不幸的是，目前的手性诱导方法主要集中在一个特定的部位。在此，我们实现了烯醇的不对称链走芳基化，以高收率和对映选择性构建多位点叔、季立体中心。这种有利于操作的新战略为未来的工业化带来了巨大的潜力。

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Facile construction of distal and diversified tertiary and quaternary stereocenters.

Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain-walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields and enantioselectivity. This new operation-friendly strategy carries substantial potential for future industrialization.

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来源期刊

Proceedings of the National Academy of Sciences of the United States of America 综合性期刊-综合性期刊

CiteScore

19.00

自引率

0.90%

发文量

3575

审稿时长

2.5 months

期刊介绍： The Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed journal of the National Academy of Sciences (NAS), serves as an authoritative source for high-impact, original research across the biological, physical, and social sciences. With a global scope, the journal welcomes submissions from researchers worldwide, making it an inclusive platform for advancing scientific knowledge.