与肥胖和妊娠糖尿病相关的母体血液和胎盘脂质组学变化中的性别二态性：一项发现研究。

IF 3 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2025-01-01 DOI:10.1016/j.placenta.2024.12.002

Leena Kadam , Marija Veličković , Kelly Stratton , Carrie D. Nicora , Jennifer E. Kyle , Eric Wang , Matthew E. Monroe , Lisa M. Bramer , Leslie Myatt , Kristin E. Burnum-Johnson

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引用次数: 0

摘要

胎盘使用脂质和其他营养物质来支持其自身的代谢，因此影响生长中的胎儿可利用的这些底物的类型和数量。产妇肥胖和妊娠期糖尿病（GDM）可破坏胎盘脂质代谢，从而导致胎儿生长改变，导致不良妊娠结局，并使后代在以后的生活中发展为疾病。因此，了解肥胖和GDM驱动的胎盘脂质代谢变化是很重要的。方法：我们收集精瘦（孕前BMI 18.5-24.9）、肥胖（BMI bbb30）或肥胖并伴有A2型GDM（4男4女）的孕妇（n = 8）足月择期剖宫产后的血浆和胎盘绒毛组织。采用LC-MS/MS分析不同脂类脂肪酸组成。GDM vs肥胖、GDM vs瘦弱、肥胖vs瘦弱的显著变化是通过胎儿性别依赖和独立的方式确定的。结果：在胎盘中检出436种脂质，其中85种有显著变化。我们报告了胎盘甘油三酯、磷脂酰胆碱和磷脂酰肌醇脂类在GDM中含有必需脂肪酸- DHA和AA的显著变化，男性胎盘驱动这些变化。在母体血浆中，鉴定出284种脂质，其中14种有显著变化，但我们没有观察到基于胎儿性别的变化。讨论：母亲肥胖和GDM影响胎盘脂质组成在两性二态的方式。特定脂类的改变可影响细胞能量学和胎盘功能。

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Sexual dimorphism in lipidomic changes in maternal blood and placenta associated with obesity and gestational diabetes: A discovery study

Introduction

The placenta uses lipids and other nutrients to support its own metabolism hence impacting the type and amount of these substrates available to the growing fetus. Maternal obesity and gestational diabetes (GDM) can disrupt placental lipid metabolism and thus lead to altered fetal growth contributing to adverse pregnancy outcomes and developmentally programing the offspring for disease in later life. Understanding obesity and GDM driven changes in placental lipid metabolism is thus important.

Methods

We collected maternal plasma and placental villous tissue following elective cesarean section at term from women who were lean (pre-pregnancy BMI 18.5–24.9), obese (BMI>30) or obese with type A2 GDM n = 8 each group (4 male and 4 female placentas). Fatty acid composition of different lipid classes was analyzed by LC-MS/MS analysis. Significant changes in GDM vs obese, GDM vs lean, and obese vs lean were determined in both a fetal sex-dependent and independent manner.

Results

In placenta 436 lipids were identified, among which 85 showed significant changes. We report significant changes in placental triglyceride, phosphatidylcholine, and phosphatidylinositol lipids containing essential fatty acids- DHA and AA in GDM, with male placentas driving these changes. In maternal plasma, 284 lipids were identified with 14 showing significant changes, but we observed no changes based on fetal sex.

Discussion

Maternal obesity and GDM impact placental lipid composition in a sexually dimorphic manner. The alteration in specific lipid classes can impact cellular energetics and placental function.

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.