静脉输注利多卡因作为阿片类药物辅助治疗住院儿童镰状细胞性血管闭塞性疼痛的安全性和耐受性

IF 2.4 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI:10.1002/pbc.31458

Ugochukwu Agbakwuru, Jacob D AuBuchon, Bobi Toebe, Anne LaBarge, Jorge Di Paola, Monica L Hulbert

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引用次数: 0

摘要

镰状细胞病（SCD）血管闭塞发作（VOE）疼痛可用阿片类药物治疗，非阿片类佐剂可减轻疼痛严重程度，且无阿片类药物副作用。我们回顾性调查了儿童和青少年在肺水肿住院期间静脉输注利多卡因作为阿片类药物辅助治疗的安全性和耐受性。在2年内，260名入院患者中有64.6%的人使用利多卡因。无严重毒性反应；总体而言，82.2%的接受者在随后的入院中选择接受利多卡因。利多卡因输注与更长的住院时间相关，可能反映了选择偏差。术前辅助输注利多卡因的疗效有待进一步研究。

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Safety and Tolerability of Intravenous Lidocaine Infusions as Opioid Adjunct for Children Hospitalized With Sickle Cell Vaso-Occlusive Pain.

Sickle cell disease (SCD) vaso-occlusive episode (VOE) pain is treated with opioids, and non-opioid adjuvants may reduce pain severity without opioid side effects. We retrospectively investigated the safety and tolerability of intravenous lidocaine infusions as an adjunct to opioids in children and adolescents during VOE hospitalizations. In 2 years, lidocaine was administered in 64.6% of 260 admissions. There were no serious toxicities; overall, 82.2% of recipients chose to receive lidocaine during subsequent admissions. Lidocaine infusions were associated with longer hospitalizations, potentially reflecting selection bias. The efficacy of adjuvant lidocaine infusions during VOE should be studied prospectively.

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.