黄杨全草多酚和三萜的研究。它们的抗炎活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-01 Epub Date: 2024-12-09 DOI:10.1016/j.fitote.2024.106337

Zhiqi Zhang, Yang Xu, Junming Liang, Dejuan Sun, Hua Li, Lixia Chen

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引用次数: 0

摘要

十二色斑瘤。是一种匍匐灌木，属于野牡丹科。它在华南地区被广泛用作药物和食品，被公认为是一种安全有效的抗炎剂。从十二香全草中分离得到35个化合物（1 ~ 35），包括2个未描述的多酚类化合物（1 ~ 2），2个未描述的三萜类化合物（3 ~ 4），28个已知的多酚类化合物（5 ~ 32）和3个已知的三萜类化合物（33 ~ 35）。基于化学证据和光谱数据分析（UV、旋光数据、1D和2D-NMR以及HR-ESI-MS），对未描述化合物的结构进行了鉴定。测定化合物1 ~ 35对lps诱导的RAW264.7细胞NO生成的抑制活性。其中化合物8的IC50值为14.50 ± 4.69 μM，抑制活性最强。

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Polyphenolics and triterpenoids from the whole herbs of Melastoma dodecandrum Lour. and their anti-inflammatory activity.

Melastoma dodecandrum Lour. is a creeping shrub belonging to the Melastomataceae family. It has been widely used as a medicine and food in South China and is recognized as a safe and effective anti-inflammatory agent. 35 compounds (1-35) were isolated from the whole herbs of M. dodecandrum, including two undescribed polyphenolics (1 and 2), two undescribed triterpenoids (3 and 4), twenty-eight known polyphenolics (5-32) and three known triterpenoids (33-35). Based on chemical evidence and spectral data analysis (UV, Optical rotation data, 1D and 2D-NMR, and HR-ESI-MS), the structures of undescribed compounds were elucidated. Compounds 1-35 were tested for their inhibitory activity on NO production in LPS-induced RAW264.7 cells. Among them, compound 8 exhibited the most excellent inhibitory activity with IC₅₀ value of 14.50 ± 4.69 μM.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.