帕金森病进展脑电图的长期时间相关性。

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-12-11 DOI:10.1002/mds.30074

Chih-Hong Lee MD, PhD, Chi-Hung Juan PhD, Hsiang-Han Chen PhD, Jia-Pei Hong MD, MPH, Ting-Wei Liao MD, Isobel French MS, Yen-Shi Lo MSc, Yi-Ru Wang BS, Mei-Ling Cheng PhD, Hsiu-Chuan Wu MD, PhD, Chiung-Mei Chen MD, PhD, Kuo-Hsuan Chang MD, PhD

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引用次数: 0

摘要

背景：帕金森病（PD）患者的运动和非运动表现均呈进行性恶化。然而，缺乏疾病进展的临床生物标志物阻碍了临床医生有效地定制治疗策略。目的：寻找可追踪帕金森病进展的脑电图（EEG）生物标志物。方法：116例PD患者首次入组，63例完成2年随访评估。58名年龄和性别匹配的健康个体被招募作为对照组。所有参与者都进行了脑电图和临床评估。采用去趋势波动分析方法对脑电数据进行了长时相关性分析。结果：PD患者左顶叶θ振荡LRTC高于对照组（P = 0.0175），中央顶叶γ振荡LRTC低于对照组（P = 0.0258）。2年内，顶叶γ振荡的LRTC与统一帕金森病评定量表（UPDRS）第三部分评分的变化呈负相关（Spearman ρ = -0.34, P = 0.0082）。左顶θ振荡LRTC增加与快速运动进展相关（P = 0.0107），定义为UPDRS第三部分评分≥3的年度增加。在认知评估中，顶枕α振荡的LRTC与2年内迷你精神状态检查和蒙特利尔认知评估分数的变化呈正相关（Spearman ρ = 0.27-0.38, P = 0.0037-0.0452）。结论：脑电图LRTC模式可能预测PD患者运动和非运动表现的快速进展，增强临床评估和对疾病的认识。©2024国际帕金森和运动障碍学会。

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Long-Range Temporal Correlations in Electroencephalography for Parkinson's Disease Progression

Background

Patients with Parkinson's disease (PD) present progressive deterioration in both motor and non-motor manifestations. However, the absence of clinical biomarkers for disease progression hinders clinicians from tailoring treatment strategies effectively.

Objectives

To identify electroencephalography (EEG) biomarker that can track disease progression in PD.

Methods

A total of 116 patients with PD were initially enrolled, whereas 63 completed 2-year follow-up evaluation. Fifty-eight age- and sex-matched healthy individuals were recruited as the control group. All participants underwent EEG and clinical assessments. Long-range temporal correlations (LRTC) of EEG data were analyzed using the detrended fluctuation analysis.

Results

Patients with PD exhibited higher LRTC in left parietal θ oscillations (P = 0.0175) and lower LRTC in centro-parietal γ oscillations (P = 0.0258) compared to controls. LRTC in parietal γ oscillations inversely correlated with changes in Unified Parkinson's Disease Rating Scale (UPDRS) part III scores over 2 years (Spearman ρ = −0.34, P = 0.0082). Increased LRTC in left parietal θ oscillations were associated with rapid motor progression (P = 0.0107), defined as an annual increase in UPDRS part III score ≥3. In cognitive assessments, LRTC in parieto-occipital α oscillations exhibited a positive correlation with changes in Mini-Mental State Examination and Montreal Cognitive Assessment scores over 2 years (Spearman ρ = 0.27–0.38, P = 0.0037–0.0452).

Conclusions

LRTC patterns in EEG potentially predict rapid progression of both motor and non-motor manifestations in PD patients, enhancing clinical assessment and understanding of the disease. © 2024 International Parkinson and Movement Disorder Society.

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.