从原子到细胞尺度观察致病菌中的抗生素作用

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-12-12 DOI:10.1038/s41594-024-01442-z

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引用次数: 0

摘要

抗生素作用的机制可能是高度具体的环境。利用肺炎支原体（一种呼吸道疾病的病原体）的细胞内冷冻电子断层扫描（cro - et），我们在原子、分子和细胞水平上同时可视化了核糖体靶向抗生素氯霉素的环境依赖性作用。这项工作强调了细胞内结构生物学如何扩大我们对抗生素作用机制的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visualizing antibiotic action in a pathogenic bacterium at atomic to cellular scale

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Visualizing antibiotic action in a pathogenic bacterium at atomic to cellular scale

The mechanisms of antibiotic action can be highly context specific. Using in-cell cryo-electron tomography (cryo-ET) of Mycoplasma pneumoniae — a causative agent of respiratory disease — we visualized the context-dependent action of the ribosome-targeting antibiotic chloramphenicol simultaneously at atomic, molecular and cellular levels. This work highlights how in-cell structural biology can expand our understanding of antibiotic mechanisms of action.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.