{"title":"二酰基化1,10-二氮杂-18-冠-6作为钙离子荧光传感器的替代模板。","authors":"Oscar G. Smith, Jennifer C. Anene, Simon Wheeler","doi":"10.1002/ansa.202400034","DOIUrl":null,"url":null,"abstract":"<p>The performance of many known fluorescent sensors for Ca<sup>2+</sup> is pH-dependent. We set out to address this by preparing a novel calcium sensor based on diacylated 1,10-diaza-18-crown-6 and containing no basic centres. The sensor is sensitive to sub-millimolar levels of Ca<sup>2+</sup> and partially tolerant of an aqueous environment. However, it suffers from a lack of selectivity over some other divalent cations, and retained pH sensitivity in the acidic range. The relations between these properties and the sensor's structure are discussed.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 11-12","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627183/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diacylated 1,10-diaza-18-crown-6 as an Alternative Template for Fluorescent Sensors of Calcium Ions\",\"authors\":\"Oscar G. Smith, Jennifer C. Anene, Simon Wheeler\",\"doi\":\"10.1002/ansa.202400034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The performance of many known fluorescent sensors for Ca<sup>2+</sup> is pH-dependent. We set out to address this by preparing a novel calcium sensor based on diacylated 1,10-diaza-18-crown-6 and containing no basic centres. The sensor is sensitive to sub-millimolar levels of Ca<sup>2+</sup> and partially tolerant of an aqueous environment. However, it suffers from a lack of selectivity over some other divalent cations, and retained pH sensitivity in the acidic range. The relations between these properties and the sensor's structure are discussed.</p>\",\"PeriodicalId\":93411,\"journal\":{\"name\":\"Analytical science advances\",\"volume\":\"5 11-12\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-11-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627183/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical science advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ansa.202400034\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical science advances","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ansa.202400034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Diacylated 1,10-diaza-18-crown-6 as an Alternative Template for Fluorescent Sensors of Calcium Ions
The performance of many known fluorescent sensors for Ca2+ is pH-dependent. We set out to address this by preparing a novel calcium sensor based on diacylated 1,10-diaza-18-crown-6 and containing no basic centres. The sensor is sensitive to sub-millimolar levels of Ca2+ and partially tolerant of an aqueous environment. However, it suffers from a lack of selectivity over some other divalent cations, and retained pH sensitivity in the acidic range. The relations between these properties and the sensor's structure are discussed.
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