肠道稳态中的2型免疫反应和疟疾中的寄生虫传播。

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-09 DOI:10.1016/j.pt.2024.11.007

Nora Céspedes, Renée M Tsolis, Adrian M Piliponsky, Shirley Luckhart

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引用次数: 0

摘要

疟疾易伴随菌血症，导致死亡风险增加。先前的研究表明，疟疾引起肠道结构改变，诱导耐受性免疫反应，抑制中性粒细胞募集，抑制先天合成IFN-γ，失调肥大细胞（MCs）和嗜碱性粒细胞，并诱导th2型免疫反应。这些措施可减少对寄生虫的控制，同时增加肠致病性传播。此外，越来越多的证据表明，Th2免疫在保护宿主免受压倒性炎症的同时，也可能导致寄生虫传播的增加。本文综述了调节免疫反应在疟疾细菌共感染和寄生虫传播中的作用。

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The type 2 immune response in gut homeostasis and parasite transmission in malaria.

Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.