工程RAFT聚合物到蛋白包覆金纳米簇用于开发荧光聚合物纳米偶联物。

IF 4.4 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Macromolecular bioscience Pub Date : 2024-12-11 DOI:10.1002/mabi.202400451

Raviteja Gaddala, Aruna Kumar Chelluboyina, Sonu Kumar

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引用次数: 0

摘要

描述了在牛血清白蛋白（BSA）蛋白稳定金纳米团簇（AuNCs@BSA）表面通过可逆加成-断裂-链转移（RAFT）聚合物的链端修饰而合成的荧光杂化纳米材料。基于“接枝到”的方法，核壳结构的纳米共轭物AuNCs@BSA/聚合物是通过亲水性和刺激响应聚合物的有效连接而产生的。通过各种微观和光谱研究对这种纳米材料进行了表征，其尺寸约为5 nm，发射峰约为650 nm。有趣的是，热敏聚合物聚二乙二醇单甲基醚甲基丙烯酸酯（PDEGMA）的偶联将纳米偶联物AuNCs@BSA/PDEGMA转化为双热/ ph响应纳米材料。

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Engineering RAFT Polymers to the Protein-capped Gold Nanoclusters for Developing Fluorescent Polymeric Nanoconjugates.

The synthesis of fluorescent hybrid nanomaterials engineered via the chain-end modification of reversible addition-fragmentation chain-transfer (RAFT) polymers on the surface of bovine serum albumin (BSA) protein-stabilized gold nanoclusters (AuNCs@BSA) is described. Based on the "grafting-to" approach the core-shell structured nanoconjugates AuNCs@BSA/polymer are generated via effective ligation of hydrophilic, and stimuli-responsive polymers. Such nanomaterials are characterized via various microscopic and spectroscopic studies and exhibit their size as ≈5 nm and emission peak at ≈650 nm. Interestingly, the conjugation of thermoresponsive polymer poly(diethylene glycol monomethyl ether methacrylate) (PDEGMA) transformed the nanoconjugates AuNCs@BSA/PDEGMA as dual thermo/pH-responsive nanomaterials.

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.