一项29-mRNA宿主反应试验用于鉴定细菌和病毒感染并预测急诊疑似感染患者30天死亡率：一项前瞻性观察队列研究

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-11-26 DOI:10.1016/j.diagmicrobio.2024.116599

Kirby Tong-Minh , Leanne van Leeuwen , Christian Ramakers , Uan-I Chen , Oliver Liesenfeld , Diederik Gommers , Eric van Gorp , Henrik Endeman , Yuri van der Does

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引用次数: 0

摘要

本研究的目的是验证29-mRNA宿主反应分类器炎症细菌-病毒-非感染-3b （IMX-BVN-3b）和严重程度-3b （IMX-SEV-3b）在识别细菌和病毒感染以及预测ed疑似感染患者30天死亡率方面的准确性。这项前瞻性观察队列研究纳入了三级急诊科疑似感染的患者。将IMX-BVN-3b与临床强制和共识判定的细菌/病毒感染状态进行比较，并将IMX-SEV-3b与30天死亡率进行比较。结果：共纳入688例患者。采用强制判定法，IMX-BVN-3b诊断细菌感染的AUC为0.76 （95% CI: 0.72 ~ 0.80）。诊断病毒感染的AUC为0.89 （95% CI 0.84 ~ 0.95）。IMX-SEV-3b的30天死亡率AUC为0.77 （95% CI: 0.68 - 0.85）。结论：29个基因宿主反应分类器IMX-BVN-3b和IMX-SEV-3b可识别急诊科疑似感染患者的病毒和细菌感染，并预测30天死亡率。

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A 29-mRNA host response test to identify bacterial and viral infections and to predict 30-day mortality in emergency department patients with suspected infections: A prospective observational cohort study

Introduction

The goal of this study is to validate the accuracy of the 29-mRNA host response classifiers Inflammatix Bacterial-Viral-Non infected-3b (IMX-BVN-3b) and Severity-3b (IMX-SEV-3b) to identify bacterial and viral infections and to predict 30-day mortality in patients with suspected infections in the ED.

Methods

This prospective observational cohort study enrolled patients with suspected infections in a tertiary ED. IMX-BVN-3b was compared to clinically forced and consensus adjudicated bacterial/viral infection status and IMX-SEV-3b was compared to 30-day mortality.

Results

A total of 688 patients were enrolled. Using forced adjudication, the AUC for the diagnosis of bacterial infection by IMX-BVN-3b was 0.76 (95 % CI: 0.72 – 0.80). The AUC for the diagnosis of viral infections was 0.89 (95 %CI 0.84-0.95). IMX-SEV-3b had an AUC of 0.77 (95 % CI: 0.68 – 0.85) on 30-day mortality.

Conclusion

The 29-gene host response classifiers IMX-BVN-3b and IMX-SEV-3b identify viral and bacterial infections and predict 30-day mortality in patients with suspected infections in the ED.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.