维生素C与乳腺癌、前列腺癌和结直肠癌之间的关系：一项系统综述和荟萃分析。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-02-01 DOI:10.1016/j.clnesp.2024.12.001

Maedeh Arshadi , Nima Ghazal , Fatemeh Ghavidel , Zahra Beygi , Zohal Nasiri , Pardis Zarepour , Sedigheh Abdollahi , Hosein Azizi , Farzad Khodamoradi

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引用次数: 0

摘要

背景：为了全面评估，并且由于之前的研究结果不一致，我们进行了这项荟萃分析，目的是维生素C对乳腺癌、前列腺癌和结直肠癌的影响。方法：检索PubMed、Scopus和Web of Science，确定截至2023年9月11日有关维生素C与乳腺癌、前列腺癌和结直肠癌之间关系的研究。合并RR和95%置信区间通过假设随机效应荟萃分析模型来衡量维生素C与乳腺癌、前列腺癌和结直肠癌之间的关系。采用纽卡斯尔-渥太华量表进行质量评价。结果：共纳入69项研究。队列研究中维生素C（饮食）与乳腺癌相关性的合并RR为0.99 [95% CI: 0.95, 1.03]，而病例对照研究的合并RR为0.72 [95% CI: 0.60, 0.85]。在研究中没有发现维生素E（补充，总摄入量）和乳腺癌之间的联系。维生素C（膳食）与前列腺癌之间的总RR为0.88 [95% CI: 0.77, 1.00]，这表明前列腺癌的发病率有所下降。在研究中没有发现维生素C（补充）和前列腺癌之间的联系。维生素C（膳食）与结直肠癌之间的总RR为0.55 [95% CI: 0.42, 0.73]，这表明结直肠癌的发病率降低。结论：我们的分析显示，在病例对照研究中，维生素C（膳食）与乳腺癌呈显著负相关。维生素C（膳食）与前列腺癌和结直肠癌之间的关系研究表明，这代表了癌症发病率的下降。

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The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis

Background

For a comprehensive evaluation and due to the inconsistent results of previous studies, we performed this meta-analysis with the aim of vitamin C effect on breast cancer and prostate cancer and colorectal cancer.

Methods

PubMed, Scopus and Web of Science were searched to identify studies on the association between vitamin C and breast cancer, prostate cancer and colorectal cancer through September 11, 2023. The pooled RR and the 95 % confidence intervals were used to measure the association between vitamin C and breast cancer, prostate cancer and colorectal cancer by assuming a random effects meta-analytic model. Newcastle–Ottawa scale was used for quality appraisal.

Results

A total of 69 studies were included. The pooled RR for the association between vitamin C (dietary) and breast cancer in the cohort study was 0.99 [95 % CI: 0.95, 1.03], but the pooled RR in the case-control study was 0.72 [95 % CI: 0.60, 0.85]. No association was found between vitamin E (supplemental, total intake) and breast cancer in studies. The pooled RR for the association between vitamin C (dietary) and prostate cancer was 0.88 [95 % CI: 0.77, 1.00], which represents a decrease in prostate cancer. No association was found between vitamin C (supplemental) and prostate cancer in studies. The pooled RR for the association between vitamin C (dietary) and colorectal cancer was 0.55 [95 % CI: 0.42, 0.73], which represents a decrease in colorectal cancer.

Conclusion

Our analysis shows an inverse significant relationship between vitamin C (dietary) and breast cancer in the case-control study. Also between vitamin C (dietary) and prostate cancer and colorectal cancer in studies, which represents a decrease in cancers.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.