以天然产品合成中的 (-)-Sclareol 为重点的可持续全合成和手性池策略的最新进展

IF 2.5 3区 化学 Q2 CHEMISTRY, ORGANIC
Ayyoub Selka, Abdelnasser Abidli, Lucie Schiavo, Loïc Jeanmart, Gilles Hanquet, William David Lubell
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Recent Advances in Sustainable Total Synthesis and Chiral Pool Strategies with Emphasis on (–)‐Sclareol in Natural Products Synthesis
Starting materials for sustainable total synthesis often come from the chiral pool: carbohydrates, cyclitols, amino acids, and terpenes. In the terpene family, (–)‐sclareol has served as a sustainable, readily available, and versatile chiral building block for the synthesis of numerous natural products. (–)‐Sclareol possesses a unique structure that has consequently promoted its integration as a core framework within various structurally complex and biologically active substances, including sesquiterpenoids, diterpenoids, and sesterterpenoids. In fact, (–)‐sclareol has facilitated access to diverse synthetic key intermediates, promoting the sustainable synthesis of several natural products. Herein, a critical and comprehensive review is presented covering the recent trends in sustainable total syntheses and the chiral pool approaches with emphasis on the synthesis of natural products through diverse synthetic routes employing (–)‐sclareol as chiral educt. Additionally, newly developed catalysts and synthetic protocols using (–)‐sclareol amongst their substrates scope are also analyzed and discussed in this review.
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来源期刊
CiteScore
5.40
自引率
3.60%
发文量
752
审稿时长
1 months
期刊介绍: The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.
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