Facile one-step synthesis of hybrid electrode based on graphitic carbon decorated by copper/copper oxide nanoparticles via laser-induced plasma processing for non-enzymatic glucose sensor

Developing a non-enzymatic glucose sensor with an adequate active surface and superior interfering resistance is essential for continuous glucose monitoring. The presented novel sensor is a facile one-step fabricated by laser-induced metal plasma forward transfer combined with plasma-driven polyimide (PI) film carbonization. Serving as the catalyst, copper (Cu)/copper oxide (CuO) nanoparticles (NPs) generated by laser-induced plasma are anchored onto the graphitic carbon (GC) conductive support. The influences of laser fluence, forward transfer distance, and Cu target thickness on the morphology and composition of the working electrode are revealed, and the electrochemical performance of the sensor is optimized. The optimized sensor demonstrates a detection limit of 7.03 nM in an alkaline solution. When glucose is supplied, the sensor responds rapidly (∼0.20s). Additionally, the sensor exhibits remarkable glucose sensing selectivity, reproducibility, and stability. The Cu/CuO NPs-GC sensor is an appealing option for future flexible non-enzymatic glucose diagnostic devices because of its ease of manufacture and performance dependability.