Yimei Wang, Xuechao Shi, Shuxian Hou, Lei Zhang, Xinxin Liu, Guoqiang Yang, Yuxuan Wang, Muwei Hao, Weiwei Zhang, Jun Wang, Fei Ge
{"title":"一种光响应多层3D多孔Ga2O3水凝胶用于光催化抗菌治疗,促进耐多药金黄色葡萄球菌感染伤口愈合","authors":"Yimei Wang, Xuechao Shi, Shuxian Hou, Lei Zhang, Xinxin Liu, Guoqiang Yang, Yuxuan Wang, Muwei Hao, Weiwei Zhang, Jun Wang, Fei Ge","doi":"10.1016/j.jmst.2024.11.022","DOIUrl":null,"url":null,"abstract":"The skin wound is susceptible to bacterial invasion, which hinders the healing of the wound, especially when infected with multi-drug resistant strains. This demands novel bioactive materials to combat bacterial infections. In this study, gallium oxide nanoparticles (Ga<sub>2</sub>O<sub>3</sub> NPs) were successfully synthesized through high-temperature thermal decomposition, exhibiting excellent biocompatibility and photocatalytic antimicrobial activity. The Ga<sub>2</sub>O<sub>3</sub> NPs were crosslinked into chitosan hydrogel to create a light-responsive multilayered 3D porous hydrogel (Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel) for use in photocatalytic antimicrobial therapy (PCAT). The prepared Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel exhibits broad-spectrum photocatalytic activity and remarkable antibacterial efficacy against <em>E. coli</em> and <em>S. aureus</em>. It effectively eradicates biofilms, promotes reactive oxygen species production, disrupts bacterial cell membranes, and induces nucleic acid leakage, ultimately resulting in bacterial death. Additionally, it exhibits excellent biosafety. Both <em>in vitro</em> pigskin and <em>in vivo</em> mouse wound infection models have confirmed the remarkable efficacy of Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel in PCAT. Notably, Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel created a moist environment for the wound in an MDR <em>S. aureus</em>-infected mouse wound model, demonstrating significant potential to facilitate wound healing and minimize scar formation. This study introduces a novel hydrogel dressing without antibiotic components for resistant bacterial-infected wounds.","PeriodicalId":16154,"journal":{"name":"Journal of Materials Science & Technology","volume":"41 1","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A light-responsive multilayered 3D porous Ga2O3 hydrogel for photocatalytic antibacterial therapy promoting healing of MDR S. aureus-infected wounds\",\"authors\":\"Yimei Wang, Xuechao Shi, Shuxian Hou, Lei Zhang, Xinxin Liu, Guoqiang Yang, Yuxuan Wang, Muwei Hao, Weiwei Zhang, Jun Wang, Fei Ge\",\"doi\":\"10.1016/j.jmst.2024.11.022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The skin wound is susceptible to bacterial invasion, which hinders the healing of the wound, especially when infected with multi-drug resistant strains. This demands novel bioactive materials to combat bacterial infections. In this study, gallium oxide nanoparticles (Ga<sub>2</sub>O<sub>3</sub> NPs) were successfully synthesized through high-temperature thermal decomposition, exhibiting excellent biocompatibility and photocatalytic antimicrobial activity. The Ga<sub>2</sub>O<sub>3</sub> NPs were crosslinked into chitosan hydrogel to create a light-responsive multilayered 3D porous hydrogel (Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel) for use in photocatalytic antimicrobial therapy (PCAT). The prepared Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel exhibits broad-spectrum photocatalytic activity and remarkable antibacterial efficacy against <em>E. coli</em> and <em>S. aureus</em>. It effectively eradicates biofilms, promotes reactive oxygen species production, disrupts bacterial cell membranes, and induces nucleic acid leakage, ultimately resulting in bacterial death. Additionally, it exhibits excellent biosafety. Both <em>in vitro</em> pigskin and <em>in vivo</em> mouse wound infection models have confirmed the remarkable efficacy of Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel in PCAT. Notably, Ga<sub>2</sub>O<sub>3</sub> NPs hydrogel created a moist environment for the wound in an MDR <em>S. aureus</em>-infected mouse wound model, demonstrating significant potential to facilitate wound healing and minimize scar formation. This study introduces a novel hydrogel dressing without antibiotic components for resistant bacterial-infected wounds.\",\"PeriodicalId\":16154,\"journal\":{\"name\":\"Journal of Materials Science & Technology\",\"volume\":\"41 1\",\"pages\":\"\"},\"PeriodicalIF\":14.3000,\"publicationDate\":\"2024-12-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Science & Technology\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jmst.2024.11.022\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Science & Technology","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1016/j.jmst.2024.11.022","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
A light-responsive multilayered 3D porous Ga2O3 hydrogel for photocatalytic antibacterial therapy promoting healing of MDR S. aureus-infected wounds
The skin wound is susceptible to bacterial invasion, which hinders the healing of the wound, especially when infected with multi-drug resistant strains. This demands novel bioactive materials to combat bacterial infections. In this study, gallium oxide nanoparticles (Ga2O3 NPs) were successfully synthesized through high-temperature thermal decomposition, exhibiting excellent biocompatibility and photocatalytic antimicrobial activity. The Ga2O3 NPs were crosslinked into chitosan hydrogel to create a light-responsive multilayered 3D porous hydrogel (Ga2O3 NPs hydrogel) for use in photocatalytic antimicrobial therapy (PCAT). The prepared Ga2O3 NPs hydrogel exhibits broad-spectrum photocatalytic activity and remarkable antibacterial efficacy against E. coli and S. aureus. It effectively eradicates biofilms, promotes reactive oxygen species production, disrupts bacterial cell membranes, and induces nucleic acid leakage, ultimately resulting in bacterial death. Additionally, it exhibits excellent biosafety. Both in vitro pigskin and in vivo mouse wound infection models have confirmed the remarkable efficacy of Ga2O3 NPs hydrogel in PCAT. Notably, Ga2O3 NPs hydrogel created a moist environment for the wound in an MDR S. aureus-infected mouse wound model, demonstrating significant potential to facilitate wound healing and minimize scar formation. This study introduces a novel hydrogel dressing without antibiotic components for resistant bacterial-infected wounds.
期刊介绍:
Journal of Materials Science & Technology strives to promote global collaboration in the field of materials science and technology. It primarily publishes original research papers, invited review articles, letters, research notes, and summaries of scientific achievements. The journal covers a wide range of materials science and technology topics, including metallic materials, inorganic nonmetallic materials, and composite materials.