一种光响应多层3D多孔Ga2O3水凝胶用于光催化抗菌治疗,促进耐多药金黄色葡萄球菌感染伤口愈合

IF 14.3 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Yimei Wang, Xuechao Shi, Shuxian Hou, Lei Zhang, Xinxin Liu, Guoqiang Yang, Yuxuan Wang, Muwei Hao, Weiwei Zhang, Jun Wang, Fei Ge
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引用次数: 0

摘要

皮肤伤口容易受到细菌侵袭,这阻碍了伤口的愈合,特别是当感染了多重耐药菌株时。这就需要新的生物活性材料来对抗细菌感染。在本研究中,通过高温热分解成功合成了氧化镓纳米颗粒(Ga2O3 NPs),具有优异的生物相容性和光催化抗菌活性。将Ga2O3 NPs交联到壳聚糖水凝胶中,制备出光响应的多层3D多孔水凝胶(Ga2O3 NPs水凝胶),用于光催化抗菌治疗(PCAT)。制备的Ga2O3 NPs水凝胶具有广谱光催化活性,对大肠杆菌和金黄色葡萄球菌具有显著的抗菌作用。它能有效地根除生物膜,促进活性氧的产生,破坏细菌细胞膜,诱发核酸泄漏,最终导致细菌死亡。此外,它还具有良好的生物安全性。体外猪皮和体内小鼠伤口感染模型均证实了Ga2O3 NPs水凝胶对PCAT的显著疗效。值得注意的是,Ga2O3 NPs水凝胶在MDR金黄色葡萄球菌感染的小鼠伤口模型中为伤口创造了湿润的环境,显示出促进伤口愈合和减少疤痕形成的巨大潜力。本研究介绍一种不含抗生素成分的新型水凝胶敷料用于耐药细菌感染的伤口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A light-responsive multilayered 3D porous Ga2O3 hydrogel for photocatalytic antibacterial therapy promoting healing of MDR S. aureus-infected wounds

A light-responsive multilayered 3D porous Ga2O3 hydrogel for photocatalytic antibacterial therapy promoting healing of MDR S. aureus-infected wounds
The skin wound is susceptible to bacterial invasion, which hinders the healing of the wound, especially when infected with multi-drug resistant strains. This demands novel bioactive materials to combat bacterial infections. In this study, gallium oxide nanoparticles (Ga2O3 NPs) were successfully synthesized through high-temperature thermal decomposition, exhibiting excellent biocompatibility and photocatalytic antimicrobial activity. The Ga2O3 NPs were crosslinked into chitosan hydrogel to create a light-responsive multilayered 3D porous hydrogel (Ga2O3 NPs hydrogel) for use in photocatalytic antimicrobial therapy (PCAT). The prepared Ga2O3 NPs hydrogel exhibits broad-spectrum photocatalytic activity and remarkable antibacterial efficacy against E. coli and S. aureus. It effectively eradicates biofilms, promotes reactive oxygen species production, disrupts bacterial cell membranes, and induces nucleic acid leakage, ultimately resulting in bacterial death. Additionally, it exhibits excellent biosafety. Both in vitro pigskin and in vivo mouse wound infection models have confirmed the remarkable efficacy of Ga2O3 NPs hydrogel in PCAT. Notably, Ga2O3 NPs hydrogel created a moist environment for the wound in an MDR S. aureus-infected mouse wound model, demonstrating significant potential to facilitate wound healing and minimize scar formation. This study introduces a novel hydrogel dressing without antibiotic components for resistant bacterial-infected wounds.
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来源期刊
Journal of Materials Science & Technology
Journal of Materials Science & Technology 工程技术-材料科学:综合
CiteScore
20.00
自引率
11.00%
发文量
995
审稿时长
13 days
期刊介绍: Journal of Materials Science & Technology strives to promote global collaboration in the field of materials science and technology. It primarily publishes original research papers, invited review articles, letters, research notes, and summaries of scientific achievements. The journal covers a wide range of materials science and technology topics, including metallic materials, inorganic nonmetallic materials, and composite materials.
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