幽门螺杆菌与标准四药抗菌药物联合治疗根除幽门螺杆菌的疗效:一项随机临床试验。

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY
JGH Open Pub Date : 2024-12-08 DOI:10.1002/jgh3.70046
Hossein Azad, Ahmad Hotrmati, Seyed S Sarkeshikian, Abolfazl Mohammadbeigi, Fatemehsadat Razavinia, Mohammad Eshaghi Far, Mehdi Pezeshgi Modarres
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引用次数: 0

摘要

背景与目的:幽门螺杆菌的治疗被认为是几个严格方案的组合,患者不满意,依从性差。益生菌在患者的抗生素治疗方案中是有效的。本研究探讨了幽门螺杆菌益生菌联合标准四药治疗幽门螺杆菌感染患者的疗效。方法:本研究为介入性研究。研究人群由幽门螺杆菌感染患者组成,采用方便抽样方法选择,随机分为两组:(i) A或标准四药治疗(阿莫西林-克拉霉素-铋-泮托拉唑)加两种安慰剂胶囊(80例)。B组或Pyloshot组(标准四药治疗加2粒Pyloshot益生菌胶囊)(90例)。治疗结束后随访1个月。根除幽门螺杆菌也评估使用粪便抗原试验。数据分析采用SPSS (v.26)统计软件。结果:从本研究结果来看,A组粪便抗原检测阴性人数少于B组,幽门螺杆菌根除(粪便抗原检测)与研究组之间无统计学意义(P = 0.20)。呕吐(P = 0.03)、腹泻(P = 0.04)、便秘(P = 0.01)、头痛(P = 0.04)的相关性有统计学意义;呕吐和便秘在对照组中最为常见。结论:根据本研究结果,幽门螺杆菌感染患者使用幽门螺杆菌益生菌治疗与标准四药治疗的疗效无显著差异。然而,用幽门射治疗组的副作用发生率较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Efficacy of Pyloshot in combination with standard four-drug antimicrobial treatment for Helicobacter pylori eradication: A randomized clinical trial

Efficacy of Pyloshot in combination with standard four-drug antimicrobial treatment for Helicobacter pylori eradication: A randomized clinical trial

Background and Aim

The treatment for Helicobacter pylori is considered to be a combination of several strict regimens, with patients' dissatisfaction and poor compliance. Probiotics are effective in patients' antibiotic regimens. This study investigated the efficacy of the Pyloshot probiotic in combination with standard four-drug therapy in patients with H. pylori infection.

Methods

This is an interventional study. The study population consisted of patients with H. pylori infection who were selected using the convenience sampling method and were randomly divided into two groups: (i) A or standard four-drug therapy (amoxicillin-clarithromycin-bismuth-pantoprazole) plus two placebo capsules (80 cases). (ii) B or Pyloshot group (standard four-drug therapy plus 2 Pyloshot probiotic capsules) (90 cases). Patients were followed up for 1 month after treatment completion. Eradication of H. pylori was also assessed using the stool antigen test. Data were analyzed using SPSS (v.26) statistical software.

Results

Based on the results from the present study, the number of negative stool antigen tests in group A was less than that in group B, and no statistically significant relationship was found between H. pylori eradication (based on stool antigen test) and the studied groups (P = 0.20). There was a statistically significant relationship between vomiting (P = 0.03), diarrhea (P = 0.04), constipation (P = 0.01), and headache (P = 0.04); vomiting and constipation were most frequent in the control group.

Conclusion

Based on the results of the present study, there was no significant difference between the effectiveness of treatment with Pyloshot probiotic and the standard four-drug therapy in patients with H. pylori infection. However, the incidence of side effects was lower in the group treated with Pyloshot.

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来源期刊
JGH Open
JGH Open GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
143
审稿时长
7 weeks
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