不同来源的抗菌肽：分离、纯化、表征及潜在应用。

IF 2.8 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of separation science Pub Date : 2024-12-09 DOI:10.1002/jssc.70043

Shadi Ali Hassen Ahmed, Bassam Saif, Linghui Qian

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引用次数: 0

摘要

抗菌肽具有良好的结构特性、高生物相容性、良好的生物降解性和功能多样性，在生物医学领域具有广阔的应用前景。与传统抗生素不同，抗菌肽已被证明对革兰氏阳性/阴性细菌具有广谱抗菌活性，以及抗真菌和抗病毒活性。这些肽也被发现对精子和癌细胞具有细胞毒性。从细菌、真菌、植物和动物等各种生物中分离出一系列抗菌肽。本文综述了抗菌肽的最新研究进展，包括抗菌肽的分离、纯化、表征及其潜在的生物医学应用前景。

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Antimicrobial Peptides From Different Sources: Isolation, Purification, and Characterization to Potential Applications

Antimicrobial peptides (AMPs) are excellent promising candidates for biomedical applications owing to their structural properties, high biocompatibility, good biodegradability, and functional diversity. Unlike conventional antibiotics, AMPs have been shown to have broad-spectrum antimicrobial activity toward Gram-positive/negative bacteria, as well as antifungal and antiviral activity. These peptides have also been found to be cytotoxic to sperm and cancer cells. A range of AMPs has been isolated from various organisms, such as bacteria, fungi, plants, and animals. This review summarizes the latest studies on AMPs, covering their isolation, purification, and characterization as well as their potential biomedical applications and beyond.

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来源期刊

Journal of separation science 化学-分析化学

CiteScore

6.30

自引率

16.10%

发文量

408

审稿时长

1.8 months

期刊介绍： The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.