Yifan Zhao, Qiao Su, Bo Zhang, Kai Xia, Lixing Zhao, Zhihe Zhao
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For clinical trials, the Cochrane RoB 2.0 tool and ROBINS-I were applied to evaluate the risk of bias in randomized clinical trials (RCTs) and controlled clinical trials (CCTs), respectively. Evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, and quantitative analysis employed RevMan software with an inverse variance method and random effects models for all included studies.</p><p><strong>Results: </strong>Most animal and human studies had a high or unclear risk of bias. LIPUS significantly accelerated OTM in rats, showing increases of 0.08 mm (95% CI, 0.02 to 0.13; P = 0.006), 0.11 mm (95% CI, 0.04 to 0.17; P = 0.001), and 0.11 mm (95% CI, 0.06 to 0.16; P < 0.0001) on days 5, 7, and 14. In clinical trials, LIPUS reduced treatment duration with clear aligners by 352.07 days (95% CI, -524.81 to -179.34; P < 0.0001), but had no significant effect on OIRR (P > 0.05). GRADE analysis indicated very low evidence quality for both outcomes.</p><p><strong>Conclusions: </strong>LIPUS may accelerate OTM but shows weak evidence for alleviating OIRR. More well-designed studies with standardized methodology are needed.</p><p><strong>Clinical relevance: </strong>LIPUS could benefit OTM acceleration, but its effect on OIRR remains inconclusive.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"6"},"PeriodicalIF":3.1000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and orthodontically induced root resorption in animal and human studies: a systematic review and meta-analysis.\",\"authors\":\"Yifan Zhao, Qiao Su, Bo Zhang, Kai Xia, Lixing Zhao, Zhihe Zhao\",\"doi\":\"10.1007/s00784-024-06096-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To evaluate the efficacy of low-intensity pulsed ultrasound (LIPUS) in orthodontic tooth movement (OTM) and orthodontically induced root resorption (OIRR) across animal and human studies.</p><p><strong>Materials and methods: </strong>An electronic search in MEDLINE, Embase, Web of Science, Cochrane Library, National Knowledge Infrastructure, and Wanfang Database up to May 2024 identified 931 records screened using predefined PICOS criteria. 18 animal and 8 human studies met the inclusion criteria, with 12 suitable for meta-analysis. Methodological qualities for animal studies were assessed using the SYRCLE tool and ARRIVE guidelines. For clinical trials, the Cochrane RoB 2.0 tool and ROBINS-I were applied to evaluate the risk of bias in randomized clinical trials (RCTs) and controlled clinical trials (CCTs), respectively. Evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, and quantitative analysis employed RevMan software with an inverse variance method and random effects models for all included studies.</p><p><strong>Results: </strong>Most animal and human studies had a high or unclear risk of bias. LIPUS significantly accelerated OTM in rats, showing increases of 0.08 mm (95% CI, 0.02 to 0.13; P = 0.006), 0.11 mm (95% CI, 0.04 to 0.17; P = 0.001), and 0.11 mm (95% CI, 0.06 to 0.16; P < 0.0001) on days 5, 7, and 14. In clinical trials, LIPUS reduced treatment duration with clear aligners by 352.07 days (95% CI, -524.81 to -179.34; P < 0.0001), but had no significant effect on OIRR (P > 0.05). GRADE analysis indicated very low evidence quality for both outcomes.</p><p><strong>Conclusions: </strong>LIPUS may accelerate OTM but shows weak evidence for alleviating OIRR. More well-designed studies with standardized methodology are needed.</p><p><strong>Clinical relevance: </strong>LIPUS could benefit OTM acceleration, but its effect on OIRR remains inconclusive.</p>\",\"PeriodicalId\":10461,\"journal\":{\"name\":\"Clinical Oral Investigations\",\"volume\":\"29 1\",\"pages\":\"6\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-12-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oral Investigations\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00784-024-06096-1\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00784-024-06096-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
目的：评价低强度脉冲超声（LIPUS）在正畸牙齿移动（OTM）和正畸诱导牙根吸收（OIRR）中的作用。材料和方法：在MEDLINE， Embase, Web of Science, Cochrane Library， National Knowledge Infrastructure和万方数据库中进行电子检索，截至2024年5月，使用预定义的PICOS标准筛选了931条记录。18项动物研究和8项人类研究符合纳入标准，其中12项适合meta分析。使用sycle工具和ARRIVE指南评估动物研究的方法学质量。临床试验方面，分别应用Cochrane RoB 2.0工具和ROBINS-I评估随机临床试验（rct）和对照临床试验（cct）的偏倚风险。证据质量采用分级推荐评估、发展和评价（GRADE）方法进行评估，定量分析采用RevMan软件，采用反方差法和随机效应模型对所有纳入的研究进行分析。结果：大多数动物和人类研究具有较高或不明确的偏倚风险。LIPUS显著加速大鼠OTM，增加0.08 mm (95% CI, 0.02 ~ 0.13；P = 0.006), 0.11 mm (95% CI, 0.04 ~ 0.17；P = 0.001), 0.11 mm (95% CI, 0.06 ~ 0.16；P 0.05)。GRADE分析显示两种结果的证据质量都很低。结论：LIPUS可能加速OTM，但减轻OIRR的证据不足。需要更多设计良好、采用标准化方法的研究。临床相关性：LIPUS可能有利于加速OTM，但其对OIRR的影响仍不确定。
Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and orthodontically induced root resorption in animal and human studies: a systematic review and meta-analysis.
Objectives: To evaluate the efficacy of low-intensity pulsed ultrasound (LIPUS) in orthodontic tooth movement (OTM) and orthodontically induced root resorption (OIRR) across animal and human studies.
Materials and methods: An electronic search in MEDLINE, Embase, Web of Science, Cochrane Library, National Knowledge Infrastructure, and Wanfang Database up to May 2024 identified 931 records screened using predefined PICOS criteria. 18 animal and 8 human studies met the inclusion criteria, with 12 suitable for meta-analysis. Methodological qualities for animal studies were assessed using the SYRCLE tool and ARRIVE guidelines. For clinical trials, the Cochrane RoB 2.0 tool and ROBINS-I were applied to evaluate the risk of bias in randomized clinical trials (RCTs) and controlled clinical trials (CCTs), respectively. Evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, and quantitative analysis employed RevMan software with an inverse variance method and random effects models for all included studies.
Results: Most animal and human studies had a high or unclear risk of bias. LIPUS significantly accelerated OTM in rats, showing increases of 0.08 mm (95% CI, 0.02 to 0.13; P = 0.006), 0.11 mm (95% CI, 0.04 to 0.17; P = 0.001), and 0.11 mm (95% CI, 0.06 to 0.16; P < 0.0001) on days 5, 7, and 14. In clinical trials, LIPUS reduced treatment duration with clear aligners by 352.07 days (95% CI, -524.81 to -179.34; P < 0.0001), but had no significant effect on OIRR (P > 0.05). GRADE analysis indicated very low evidence quality for both outcomes.
Conclusions: LIPUS may accelerate OTM but shows weak evidence for alleviating OIRR. More well-designed studies with standardized methodology are needed.
Clinical relevance: LIPUS could benefit OTM acceleration, but its effect on OIRR remains inconclusive.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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