与123I-MIBG SPECT/CT相比，68Ga-DOTATATE PET/CT显示小儿神经母细胞瘤患者轻脑膜转移病灶更多。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-04-01 Epub Date: 2024-12-09 DOI:10.1097/RLU.0000000000005630

Lingling Zheng, Siqi Li, Yanfeng Xu, Wei Wang, Jigang Yang

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引用次数: 0

摘要

摘要：对1例5岁高危神经母细胞瘤患者行123I-MIBG SPECT/CT和68Ga-DOTATATE PET/CT检查。脑MRI增强显示右脑顶叶2个转移灶。一个病变显示异常的MIBG积累与右侧中央后回高密度相关，而另一个病变未显示MIBG摄取。相反，在两个病变中均可见68Ga-DOTATATE摄取增加。脑脊液细胞学检查发现神经母细胞瘤细胞。

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68 Ga-DOTATATE PET/CT Demonstrated More Lesions of Leptomeningeal Metastases Compared With 123 I-MIBG SPECT/CT in a Pediatric Neuroblastoma Patient.

Abstract: A 5-year-old girl with high-risk neuroblastoma after therapy was evaluated by 123 I-MIBG SPECT/CT and 68 Ga-DOTATATE PET/CT. Contrast-enhancement brain MRI demonstrated 2 metastatic lesions in the right parietal lobe of brain. One lesion showed abnormal MIBG accumulation associated with high density in the right central posterior gyrus, whereas the other lesion did not show MIBG uptake. In contrast, increased 68 Ga-DOTATATE uptake was seen in both lesions. Neuroblastoma cells were found by cytological examination of the cerebrospinal fluid.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.