簇状细胞作为辐照后的储备干细胞促进人肠上皮再生。

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2024-12-09 DOI:10.1186/s13619-024-00214-w

Yehua Li, Mengxian Zhang, Xianrun Ma, Ye-Guang Chen

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引用次数: 0

摘要

肠上皮再生对维持肠道功能的稳态至关重要。最近发表在《自然》杂志上的一项研究揭示了簇状细胞在再生过程中是一个意想不到的关键角色。人类簇状细胞，传统上被认为参与免疫防御和病原体保护，被发现在辐射诱导损伤后表现出干细胞样特性。这些细胞不仅能够抵抗损伤，而且能够产生功能性干细胞，促进肠上皮的修复。这一发现表明，簇状细胞可能作为干细胞的储备库，对损伤后肠道的有效再生至关重要。

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Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation.

Intestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions. A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process. Human tuft cells, traditionally recognized for their involvement in immune defense and pathogen protection, were found to exhibit stem cell-like properties following radiation-induced injury. These cells not only resist damage but also have the ability to generate functional stem cells, promoting the repair of the intestinal epithelium. This finding suggests that tuft cells may function as a reserve pool of stem cells, essential for efficient intestinal regeneration after injury.

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine