环氧化物的开环:合成多酮和相关立体富集天然产物的简便方法:综述。

IF 3.9 2区 化学 Q2 CHEMISTRY, APPLIED
Madiha Hanif, Asim Mansha, Kulsoom Ghulam Ali, Muhammad Athar Saeed, Shahid Mahmood, Aijaz Rasool Chaudhry, Ahmad Irfan, Aqsa Mushtaq, Ameer Fawad Zahoor
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引用次数: 0

摘要

环氧化物是多种天然产物结构组成中的重要杂环。环氧化物的开环反应已成为合成各种功能化分子的多用途高效策略。此类反应已被广泛应用于制备复杂的天然产物。科学界对环氧化物开环反应的关注与日俱增,其原因是人们希望了解如何合成具有重要生物学和结构意义的化合物。在本文中,我们简要介绍了自过去十年(2014-2023 年)以来,环氧化物开环反应在合成多酮类化合物和相关天然化合物中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ring opening of epoxides: a facile approach towards the synthesis of polyketides and related stereoenriched natural products: a review.

Epoxides are significant heterocycles in the structural makeup of a variety of natural products. Their ring-opening reactions have emerged as a versatile and efficient strategies for synthesizing a variety of functionalized molecules. Such reactions have been extensively applied towards the preparation of complex naturally occurring products. The focus on epoxide ring-opening reactions within the scientific community has been increased, influenced by the goal to understand the synthesis of compounds that are important for their biological and structural significance. In this article, we have provided a concise account on the applications of epoxide's ring cleavage towards the syntheses of polyketides and related naturally occurring compounds, documented since last decade (2014-2023).

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来源期刊
Molecular Diversity
Molecular Diversity 化学-化学综合
CiteScore
7.30
自引率
7.90%
发文量
219
审稿时长
2.7 months
期刊介绍: Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;
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