国际血清液细胞病理学报告系统在巴西城市的适用性。

IF 1.6 4区医学 Q3 PATHOLOGY

Acta Cytologica Pub Date : 2024-12-09 DOI:10.1159/000543045

Caio Rodrigo Dos Santos, Daniel José da Silva, Deolino Joao Camilo Junior, José Cândido Xavier-Junior

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引用次数: 0

摘要

简介：国际细胞学学会和美国细胞病理学学会开发了国际浆液细胞病理学系统（TIS）来规范细胞学报告。胸膜腔、腹膜腔和心包腔的积液是医学诊断的宝贵信息来源，特别是在肿瘤情况下。TIS的分类分为五类：非诊断性（ND）、恶性阴性（NFM）、意义不确定的异型（AUS）、疑似恶性（SFM）和恶性（MAL）。它促进了专家之间的全球交流，旨在制定基于恶性肿瘤风险评估的未来临床管理指南。方法：本定量分析和回顾性研究评估了2017年1月至2022年12月期间从巴西圣保罗公立和私立医院送到araparatuba病理学研究所（IPAT）的浆液（胸膜、心包和腹膜）。流行病学和临床资料收集自机构档案，包括活组织检查和免疫组织化学结果。结果：该研究包括719例患者，分析了6年来763份浆液样本（心包、胸膜和腹膜）。大多数样本来自胸腔积液(n = 438；57.4%)，其次是腹膜(n = 293；38.4%)和心包积液(n = 32；4.2%)。样本采用国际浆液细胞病理学系统（TIS）分类，分布如下：ND（0.41%）、NFM（70.30%）、AUS（0.95%）、SFM（11.90%）和MAL（16.44%）。各分类的恶性危险度分别为：ND 66.67%、NFM 23.39%、AUS 28.57%、SFM 48.28%、MAL 84.17%。结论：所有类别的ROM均超出了TIS所建议的间隔。这些发现表明，即使在癌症中心环境之外，TIS也适用，尽管所呈现的ROM频率超出了推荐范围。

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Applicability of the International Cytopathology Reporting System of Serous Fluids in a Brazilian City.

Introduction: The International Academy of Cytology and the American Society of Cytopathology developed the International System of Serous Fluid Cytopathology (TIS) to standardize cytological reports. Effusions in pleural, peritoneal, and pericardial cavities are valuable sources of information for medical diagnosis, especially in oncological scenarios. The TIS classification is divided into five categories: non-diagnostic (ND), negative for malignancy (NFM), atypia of uncertain significance (AUS), suspected malignancy (SFM), and malignant (MAL). It facilitates global communication between specialists, aiming for future clinical management guidelines based on malignancy risk assessment.

Methods: This quantitative analytical and retrospective study evaluated serous fluids (pleural, pericardial, and peritoneal) sent to the Instituto de Patologia de Araçatuba (IPAT), São Paulo, Brazil, from public and private hospitals between January 2017 and December 2022. Epidemiological and clinical data were collected from institutional files, including biopsies and immunohistochemical results.

Results: The study included 719 patients with 763 serous fluid samples (pericardial, pleural, and peritoneal) analyzed over six years. The majority of samples were from pleural effusions (n = 438; 57.4%), followed by peritoneal (n = 293; 38.4%) and pericardial effusions (n = 32; 4.2%). Samples were classified using the International Serous Fluid Cytopathology System (TIS), revealing the following distribution: ND (0.41%), NFM (70.30%), AUS (0.95%), SFM (11.90%), and MAL (16.44%). The risk of malignancy calculated for each category were ND 66.67%, NFM 23.39%, AUS 28.57%, SFM 48.28%, and MAL 84.17%.

Conclusion: The ROM was out of the interval proposed by the TIS in all categories. These findings suggest the applicability of TIS even outside of the cancer center environment, although the presented ROM frequencies were out of the recommended range.

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.