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用于定量缺氧神经元中硝基还原酶的比例双光子荧光探针。

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chemical Communications Pub Date : 2024-11-26 DOI:10.1039/d4cc06218c
Zhiquan Tang , Hong Huang , Yuanyuan Yao , Shumei Gao , Bingyong Lin , Qianshou Zong , Wanpeng Hu , Jianguo Xu , Yangang Wang , Longhua Guo
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引用次数: 0

摘要

我们开发了一种新的比率双光子荧光探针，用于选择性和精确检测神经元中的硝基还原酶（NTR）。利用这种探针，我们发现缺氧刺激可以上调内源性NTR水平。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons†

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A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons†
We developed a novel ratiometric two-photon fluorescent probe for the selective and precise detection of nitroreductase (NTR) in neurons. Using this probe, we found that hypoxic stimulation could up-regulate endogenous NTR levels.
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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