IF 2.1 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Peiyan Du, Jianxiang Jiang, Yurong Liu, Haihong Lv
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引用次数: 0

摘要

目的:代谢功能障碍相关性脂肪肝(MAFLD)T2DM患者的血管内皮功能与骨矿物质密度(BMD)之间的关系仍不清楚。本研究旨在分析代谢功能障碍伴脂肪肝 T2DM 患者的血管内皮功能与骨密度或骨折风险之间的相关性:方法:共纳入 872 名年龄≥50 岁的 T2DM 患者,根据 MAFLD 诊断标准分为两组:MAFLD(+)和 MAFLD(-)。通过高分辨率超声波测量血流介导的扩张(FMD),以反映血管内皮功能。通过双能 X 射线骨密度测量法测量 BMD,并计算 10 年髋部骨折风险(HF1)和主要骨质疏松性骨折风险(MOF)的 FRAX 评分:经多变量调整后,MAFLD(-)组的 FMD 与 BMD 之间无明显相关性(P > 0.05)。在 MAFLD (+) 组和 FMD < 4% 组中,FMD 与 WB、LS 和 FN BMD 呈正相关,而 FMD 与骨折风险和骨质疏松性骨折史呈负相关,且仅在女性患者中观察到这种相关性。然而,在 4%≤FMD ≤ 7% 和 FMD > 7% 组中,FMD 与 BMD、骨折风险和骨质疏松性骨折病史无关:结论:在患有 MAFLD 的 T2DM 患者中,FMD 与 BMD 的关系因 FMD 水平而异。在 FMD < 4% 组的女性患者中,FMD 的降低与 BMD 的降低和骨折风险的增加有关。FMD 可能是骨质疏松症发生和发展的一个影响因素,对于早期诊断患有 MAFLD 的 T2DM 患者的骨质疏松症具有一定的临床价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between vascular endothelial function and bone mineral density in type 2 diabetes mellitus patients with MAFLD.

Objective: The relationship between vascular endothelial function and bone mineral density (BMD) in T2DM patients with metabolic dysfunction associated fatty liver (MAFLD) is still unclear. This study aims to analyse the correlation between vascular endothelial function and BMD or fracture risk in T2DM patients with MAFLD.

Methods: A total of 872 T2DM patients aged ≥50 years were enrolled and divided into two groups according to the diagnostic criteria of MAFLD: MAFLD (+) and MAFLD (-). Flow-mediated dilation (FMD) was measured by high-resolution ultrasound to reflect vascular endothelial function. BMD was measured by dual-energy X-ray bone densitometry, and FRAX scores were calculated for 10-year hip fracture risk (HF1) and major osteoporotic fracture risk (MOF).

Results: After multivariate adjustment, there was no significant correlation between FMD and BMD in MAFLD (-) group (p > 0.05). In MAFLD (+) and FMD < 4% group, FMD was positively correlated with WB, LS, and FN BMD, while FMD was negatively correlated with fracture risk and osteoporotic fracture history, and this correlation was only observed in female patients. However, FMD was not correlated with BMD and fracture risk and osteoporotic fracture history in 4%≤FMD ≤ 7% and FMD > 7% groups.

Conclusions: The association of FMD with BMD in T2DM patients with MAFLD varies according to FMD level. The decrease of FMD is associated with reduced BMD and increased fracture risk in female patients with FMD < 4% group. FMD may be an influential factor for the occurrence and development of osteoporosis, and has some clinical value in early diagnosis of osteoporosis in T2DM patients with MAFLD.

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来源期刊
Acta cardiologica
Acta cardiologica 医学-心血管系统
CiteScore
2.50
自引率
12.50%
发文量
115
审稿时长
2 months
期刊介绍: Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.
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