Jane Hawkey, Lise Frézal, Alicia Tran Dien, Anna Zhukova, Derek Brown, Marie Anne Chattaway, Sandra Simon, Hidemasa Izumiya, Patricia I. Fields, Niall De Lappe, Lidia Kaftyreva, Xuebin Xu, Junko Isobe, Dominique Clermont, Elisabeth Njamkepo, Yukihiro Akeda, Sylvie Issenhuth-Jeanjean, Mariia Makarova, Yanan Wang, Martin Hunt, Brent M. Jenkins, Magali Ravel, Véronique Guibert, Estelle Serre, Zoya Matveeva, Laëtitia Fabre, Martin Cormican, Min Yue, Baoli Zhu, Masatomo Morita, Zamin Iqbal, Carolina Silva Nodari, Maria Pardos de la Gandara, François-Xavier Weill
{"title":"引起乙型副伤寒的芽孢杆菌的基因组研究","authors":"Jane Hawkey, Lise Frézal, Alicia Tran Dien, Anna Zhukova, Derek Brown, Marie Anne Chattaway, Sandra Simon, Hidemasa Izumiya, Patricia I. Fields, Niall De Lappe, Lidia Kaftyreva, Xuebin Xu, Junko Isobe, Dominique Clermont, Elisabeth Njamkepo, Yukihiro Akeda, Sylvie Issenhuth-Jeanjean, Mariia Makarova, Yanan Wang, Martin Hunt, Brent M. Jenkins, Magali Ravel, Véronique Guibert, Estelle Serre, Zoya Matveeva, Laëtitia Fabre, Martin Cormican, Min Yue, Baoli Zhu, Masatomo Morita, Zamin Iqbal, Carolina Silva Nodari, Maria Pardos de la Gandara, François-Xavier Weill","doi":"10.1038/s41467-024-54418-4","DOIUrl":null,"url":null,"abstract":"<p>Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of <i>Salmonella enterica</i> serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of <i>gyrA</i> and <i>gyrB</i>. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"38 1","pages":""},"PeriodicalIF":15.7000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genomic perspective on the bacillus causing paratyphoid B fever\",\"authors\":\"Jane Hawkey, Lise Frézal, Alicia Tran Dien, Anna Zhukova, Derek Brown, Marie Anne Chattaway, Sandra Simon, Hidemasa Izumiya, Patricia I. Fields, Niall De Lappe, Lidia Kaftyreva, Xuebin Xu, Junko Isobe, Dominique Clermont, Elisabeth Njamkepo, Yukihiro Akeda, Sylvie Issenhuth-Jeanjean, Mariia Makarova, Yanan Wang, Martin Hunt, Brent M. Jenkins, Magali Ravel, Véronique Guibert, Estelle Serre, Zoya Matveeva, Laëtitia Fabre, Martin Cormican, Min Yue, Baoli Zhu, Masatomo Morita, Zamin Iqbal, Carolina Silva Nodari, Maria Pardos de la Gandara, François-Xavier Weill\",\"doi\":\"10.1038/s41467-024-54418-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of <i>Salmonella enterica</i> serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of <i>gyrA</i> and <i>gyrB</i>. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.</p>\",\"PeriodicalId\":19066,\"journal\":{\"name\":\"Nature Communications\",\"volume\":\"38 1\",\"pages\":\"\"},\"PeriodicalIF\":15.7000,\"publicationDate\":\"2024-12-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Communications\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1038/s41467-024-54418-4\",\"RegionNum\":1,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Communications","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41467-024-54418-4","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Genomic perspective on the bacillus causing paratyphoid B fever
Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.
期刊介绍：
Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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