加速：神经肽促进T辅助1细胞的命运

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-12-10 DOI:10.1016/j.immuni.2024.11.013

Camille A. Spinner, Vanja Lazarevic

引用次数: 0

摘要

CD4+辅助性T细胞（Th）分化依赖于强制谱系承诺同时抑制替代命运的调控网络。在最近一期的《自然》杂志上，侯等人揭示了降钙素基因相关肽（CGRP）指导Th1的承诺，强调了T细胞命运决定中的神经免疫串扰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Getting RAMPed up: Neuropeptides boost T helper 1 cell fate

CD4⁺ T helper (Th) cell differentiation depends on regulatory networks that enforce lineage commitment while suppressing alternative fates. In a recent issue of Nature, Hou et al. reveal that calcitonin gene-related peptide (CGRP) directs Th1 commitment, highlighting neuro-immune crosstalk in T cell fate decisions.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.