配对交换活体肝移植：来自土耳其的单中心经验。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2024-12-07 DOI:10.1016/j.transproceed.2024.11.002

Ayhan Dinckan , Eryigit Eren , Fatih Ensaroglu , Taylan Sahin , Hakan Parlak , Ali Kocyigit , Utku Alkara , Murat Akyildiz , Mehmet Tokac

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引用次数: 0

摘要

背景：在死亡供体实体器官移植率较低的国家，活体供体肝移植是终末期肝病儿童和成人首选的最终治疗方法。然而，众所周知，大量潜在的活体肝脏供体由于ABO不相容、肝脏质量不理想或解剖特征而被排斥。配对交换肝移植（PELT）的实践克服了这些障碍。在此，我们提出了我们的PELT单中心经验的结果，并将其与先前报道的数据进行比较。方法：2015年1月至2022年12月期间接受PELT的患者构成目标人群。收集的受体数据包括人口统计学参数、终末期肝病评分模型、移植物受体体重比、肝移植和配对交换适应症、体重指数、住院时间、重症监护病房住院时间、术后并发症和住院死亡率。检索供体资料，包括人口统计学特征、体重指数、肝移植物类型（右叶或左外侧节段）、移植物重量(g)、门静脉解剖类型（1、2或3型）、胆道解剖类型（1、2、3a、3b型）、住院时间、并发症和死亡率。结果：18例患者中，男性14例（78%），女性4例（22%）。受者平均年龄为50.7岁[2-66岁]，供者平均年龄为29.3岁[18-40岁]。平均随访31.9[12-71]个月。患者1年生存率为83.3%，移植物1年生存率为88.9%。结论：在具有丰富LDLT经验的移植中心，PELT是完全可行的。

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Paired Exchange Living Donor Liver Transplantation: A Single Center Experience From Turkiye

Background

In countries with low rates of deceased donor solid organ transplantations, live-donor liver transplantation is the preferred definitive treatment for children and adults with end-stage liver disease. However, it is known that a remarkable number of potential living liver donors are rejected due to ABO incompatibility, suboptimal liver mass, or anatomical features. Paired exchange liver transplantation (PELT) practice emerged to overcome these obstacles. Herein, we present the results of our single-center experience with PELT and compare them with previously reported data.

Methods

Patients who underwent PELT between January 2015 and December 2022 constituted the target population. The collected recipient data included demographic parameters, the model for end-stage liver disease score, graft-recipient weight ratio, indication for LT and paired exchange, body-mass index, duration of hospital stay, duration of intensive care unit stay, postoperative complications and inpatient mortality. Donor data, including demographic characteristics, body mass index, type of liver graft (right lobe or left lateral segment), graft weight (g), type of portal vein anatomy (Type 1, 2, or 3), type of biliary anatomy (Type 1, 2, 3a, 3b), duration of hospital stay, complications and mortality were retrieved.

Results

Among 18 recipients, 14 (78%) were male, and 4 (22%) were female. The mean recipient age was 50.7 [2-66], while the mean donor age was 29.3 [18-40]. The mean follow-up period was 31.9 [12-71] months. The 1-year patient and graft survivals were calculated as 83.3% and 88.9%.

Conclusion

The PELT can be utterly feasible at transplant centers with remarkable LDLT experience.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.