神经精神事件与系统性红斑狼疮临床表现的关系:一项荟萃分析。

Ying Liu, Qianru Guo, Pingping Yu, Liyun Zhang, Na Yuan, Xinmei Song
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引用次数: 0

摘要

揭示系统性红斑狼疮(SLE)患者包括其亚群神经精神系统红斑狼疮(NPSLE)患者的临床特点,探讨其精神病学表现的根本原因。通过对PubMed、Embase、Medline和Cochrane的综合数据库检索,从其成立到2023年8月,该研究的重点是成人SLE和NPSLE病例。从选定的研究中,通过随机效应荟萃分析综合了数据,包括六项研究中的2,997名受试者。研究结果强调了SLE和NPSLE患者在盘状皮疹、高血压、平均病程和各种自身抗体等医学指标上的差异,表明有必要采取细致入微的治疗方法,特别是NPSLE需要延长治疗时间。分析表明,这些表现背后的因果关系是多因素的,包括精神状态、自身抗体谱和环境因素,从而为SLE和NPSLE的临床管理和理解提供了有价值的见解。本研究强调了SLE的复杂性,特别是其神经精神表现,并强调了靶向治疗策略的重要性。关键词:系统性红斑狼疮,神经精神性系统性红斑狼疮,神经精神事件,meta分析
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Neuropsychiatric Event and Systemic Lupus Erythematosus Clinical Manifestation: A Meta-Analysis.

To uncover the clinical characteristics and investigate the underlying causes of psychiatric manifestations in patients with systemic lupus erythematosus (SLE), including its subset, neuropsychiatric systemic lupus erythematosus (NPSLE). Through comprehensive database searches in PubMed, Embase, Medline, and Cochrane, from their inception to August 2023, the study focused on adult SLE and NPSLE cases. From the selected studies, data were synthesised via a random-effects meta-analysis, encompassing a total of 2,997 subjects across six studies. The findings highlighted differences in medical indicators such as discoid rash, hypertension, mean disease duration, and various autoantibodies between SLE and NPSLE patients, indicating a nuanced approach to treatment is necessary, particularly with NPSLE requiring extended treatment periods. The analysis suggests that the causality behind these manifestations is multifactorial, encompassing mental state, autoantibody profiles, and environmental factors, thus providing valuable insights into the clinical management and understanding of SLE and NPSLE. This study emphasises the complexity of SLE, particularly in its neuropsychiatric manifestations, and underscores the importance of targeted treatment strategies. Key Words: Systemic lupus erythematosus, Neuropsychiatric systemic lupus erythematosus, Neuropsychiatric event, Meta-analysis.

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