泰国怀孕农场工人配对血清和母乳样本中的全氟烷基和多氟烷基物质。

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health Pub Date : 2024-12-07 DOI:10.1016/j.ijheh.2024.114509

Stephanie M. Eick , Neha Sehgal , Amina Salamova , Nancy Fiedler , Robert B. Hood , Volha Yakimavets , Nattawadee Promkam , Tippawan Prapamontol , Panrapee Suttiwan , Supattra Sittiwang , Ampica Mangklabruks , Warangkana Naksen , Parinya Panuwet , Dana Boyd Barr

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引用次数: 0

摘要

全氟烷基和多氟烷基物质（PFAS）在孕妇体内被广泛检测到，并可转移到子宫内发育中的胎儿体内。母乳喂养可能是婴儿接触PFAS的一个重要来源。然而，量化母乳样本中PFAS水平的研究仍然很少，特别是在低收入和中等收入国家。我们在泰国的母婴对中检查了母乳作为产后PFAS暴露源。怀孕的农场工人在2017年至2019年期间参加了亚洲妇女及其后代发育和环境暴露研究（SAWASDEE），这是泰国北部的一个前瞻性出生队列。我们量化了在妊娠中期获得的母体血清样本中8种PFAS的水平，以及在婴儿9.5个月和11.5个月获得的母乳样本（N = 46对配对）。对于每个PFAS，我们计算了泌乳（血清到乳）转移效率和泌乳估计日摄入量。血清样品中PFOA、PFOS、PFHxS、PFNA、PFDA和PFUnDA的检出率为50% ~ 90%。在9.5个月和11.5个月的母乳样本中，有60%的母乳样本检测到全氟辛烷磺酸，而在9.5个月的母乳样本中，只有50%的母乳样本检测到全氟辛烷磺酸。所有剩余PFAS均在

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Per- and polyfluoroalkyl substances in paired serum and breastmilk samples among pregnant farmworkers in Thailand

Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant persons and can be transferred to the developing fetus in utero. Breastfeeding may represent an important source of PFAS exposure for infants. However, studies quantifying levels of PFAS in breastmilk samples remain scarce, particularly in low- and middle-income countries. We examined breastmilk as a postnatal PFAS exposure source among mother-infant pairs in Thailand. Pregnant farmworkers were enrolled in the Study of Asian Women and their Offspring's Development and Environmental Exposures (SAWASDEE), a prospective birth cohort in Northern Thailand, between 2017 and 2019. We quantified levels of eight PFAS in maternal serum samples obtained during the second trimester, as well as in breastmilk samples obtained at 9.5 months and 11.5 months in infancy (N = 46 matched pairs). For each PFAS, we calculated lactational (serum to milk) transfer efficiencies and lactational estimated daily intake. PFOA, PFOS PFHxS, PFNA, PFDA, and PFUnDA were detected in >90% of serum samples. PFOS was detected in >60% of breastmilk samples obtained at 9.5 and 11.5 months, while PFNA was detected in >50% of 9.5-month breastmilk samples only. All remaining PFAS were detected in <50% of breastmilk samples. The lactational transfer efficiency for PFOS was 7.03% (SD = 5.78) and 5.83% (SD = 5.21) at 9.5 and 11.5 months, respectively. The lactational estimated daily intake for PFOS was 12.1 ng/kg bodyweight/day (SD = 5.49) and 10 ng/kg bodyweight/day (SD = 6.22) at 9.5 and 11.5 months, respectively. For PFNA, the lactational transfer efficiency and estimated daily intake at 9.5 months was 14.7% (SD = 14.3) and 6.14% (SD = 3.40), respectively. Within one of the first PFAS biomonitoring studies conducted in Thailand, we found that legacy PFAS were widely detected in serum, and some compounds were also detected in breastmilk of farmworkers. This study provides new evidence enhancing our understanding of postnatal exposure to PFAS.

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来源期刊

International journal of hygiene and environmental health 医学-传染病学

CiteScore

11.50

自引率

5.00%

发文量

151

审稿时长

22 days

期刊介绍： The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.