根据口腔分区，边缘较近对口腔癌预后的影响

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-12-09 DOI:10.1002/hed.28024

Patrick Sheahan, Deirdre Callanan, Nadia van den Berg, Justin Hintze, David Brinkman, Hadeel Jawad, Ryan O'Sullivan, Ross O'Shea, Andrew Dias, Linda Feeley

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引用次数: 0

摘要

背景：口腔鳞状细胞癌（OSCC）边缘闭合的预后意义尚存争议。我们希望根据口腔亚部位研究癌缘闭合对OSCC局部复发（LR）风险的影响。方法：对342例接受外科手术治疗的OSCC患者进行回顾性队列研究。手术边缘以主要标本为基础，定义为阳性（边缘鳞状细胞癌）、闭合(结果：舌鳞状细胞癌病例中，阳性（风险比13.48,95% CI 2.03, 32.91）和闭合（风险比3.87,95% CI 1.31, 11.34）与LR显著相关。结论：根据口腔亚部位的不同，舌缘闭合对OSCC的LR有不同的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Impact of Close Margins on Oral Cancer Outcomes According to the Oral Subsite.

Background: The prognostic significance of close margins in oral squamous cell carcinoma (OSCC) is controversial. We wished to investigate the impact of close margins on the risk of local recurrence (LR) in OSCC according to the oral subsite.

Methods: A retrospective cohort study of 342 OSCC patients undergoing primary surgical treatment was conducted. Surgical margins were based on the main specimen and defined as positive (SCC at margins), close (< 5 mm), or clear (≥ 5 mm).

Results: Among tongue SCC cases, both positive (hazard ratio 13.48, 95% CI 2.03, 32.91) and close margins (hazard ratio 3.87, 95% CI 1.31, 11.34) were significantly associated with LR. Tongue margins < 4 mm were associated with higher LR. Among non-tongue SCC cases, only positive margins (hazard ratio 4.10, 95% CI 1.19, 14.21) were associated with LR. Close margins were not significant (hazard ratio 1.59, 95% CI 0.46, 5.42).

Conclusions: Close margins appear to have a differential impact on LR in OSCC according to the oral subsite.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.