不同严重程度的实验性自身免疫性葡萄膜炎中的t细胞反应

Q4 Medicine

Ceska a Slovenska Oftalmologie Pub Date : 2024-01-01 DOI:10.31348/2024/44

Nadiia Kuryltsiv, Oleksandra Zborovska, Liudmyla Velychko, Aleksandra Bohdanova

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引用次数: 0

摘要

目的：探讨不同严重程度的实验性自身免疫性葡萄膜炎（EAU）兔的t细胞免疫反应动力学。材料与方法：实验分为两组，每组15只。创建了EAU的模型。评估不同严重程度的眼内炎症的临床表现。测定家兔血液中白细胞（WBC）、淋巴细胞（淋巴细胞）、CD3+、CD4+、CD8+、CD16+水平。结果：ⅰ组为中重度葡萄膜炎，ⅱ组为轻度葡萄膜炎。在实验的所有天（3,7,10,14,21天），两组动物的WBC，淋巴细胞，CD3+, CD4+， CD16+均升高，且与对照参数相比具有统计学意义(p。

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T-Cells Response in Experimental Autoimmune Uveitis of Varying Severity.

Aim: to investigate the dynamics of the T-cell immune response in rabbits with experimental autoimmune uveitis (EAU) of varying severity.

Materials and methods: The experiment involved two groups of Chinchilla rabbits (15 rabbits in each group). The model of EAU was created. The clinical picture of intraocular inflammation of varying severity was assessed. The determination of the level of white blood cells (WBC), lymphocytes (Lymphs), CD3+, CD4+, CD8+, and CD16+ in the blood of rabbits was conducted.

Results: Group I - moderate and severe uveitis, Group II - uveitis of mild severity. WBC, Lymphs, CD3+, CD4+, CD16+ were elevated and statistically significant in both groups of animals compared to control parameters on all days of the experiment (3, 7, 10, 14, 21 days) (p.

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来源期刊

Ceska a Slovenska Oftalmologie Medicine-Ophthalmology

CiteScore

0.80

自引率

0.00%

发文量

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