- Book学术

发布求助

文献互助智能选刊最新文献

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2024-12-09 DOI:10.1111/1756-185X.15448

Kunihiro Yamaoka, Naonobu Sugiyama, Masato Hoshi, Joo-Young Jo, Kichul Shin, Toshitaka Hirano

{"title":"Risk Factors Associated With Major Adverse Cardiovascular Events and Malignancies in Patients With Rheumatoid Arthritis in a Real-World Setting in Japan","authors":"Kunihiro Yamaoka, Naonobu Sugiyama, Masato Hoshi, Joo-Young Jo, Kichul Shin, Toshitaka Hirano","doi":"10.1111/1756-185X.15448","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To identify risk factors associated with major adverse cardiovascular events (MACE) and malignancies in patients with rheumatoid arthritis (RA) using real-world data from Japan.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This cohort study used the Real World Data database of medical institutions in Japan. Eligible patients (January 2013–December 2021) had ≥ 1 RA diagnosis, were aged ≥ 18 years, prescribed ≥ 1 antirheumatic drug, had no psoriasis diagnosis, and had a record postindex. Patients had no myocardial infarction/stroke ≤ 31 days (MACE cohort) or malignancy < 1 year (malignancy cohort) before index. Cohorts were determined by incidence of initial MACE or malignancy. Known/exploratory variables were selected using Cox regression models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Across MACE (<i>n</i> = 16 012) and malignancy (<i>n</i> = 14 545) cohorts, most patients were female and aged ≥ 65 years. Overall, 214 MACE per 43964.7 patient-years (incidence rate 0.49 per 100 patient-years) and 315 malignancies per 40251.6 patient-years (incidence rate 0.78 per 100 patient-years) occurred. Male sex, older age (≥ 65 years), hypertension, renal disease, cerebrovascular disease, and prior X-ray examination were significantly associated with increased MACE risk. Male sex, older age (≥ 50 years), nonsteroidal anti-inflammatory drug use, emphysema, serious infection, malignancy history, and prior X-ray examination were significantly associated with increased malignancy risk. Conversely, glucocorticoid use and fracture diagnosis were significantly associated with reduced malignancy risk.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In patients with RA in Japan, male sex, older age, and prior X-ray examination were associated with increased MACE and malignancy risk.</p>\n </section>\n </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626545/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Rheumatic Diseases","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.15448","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：利用日本的真实世界数据，确定类风湿关节炎（RA）患者发生主要不良心血管事件（MACE）和恶性肿瘤的相关风险因素：这项队列研究使用了日本医疗机构的真实世界数据数据库。符合条件的患者（2013 年 1 月至 2021 年 12 月）≥ 1 次类风湿关节炎诊断，年龄≥ 18 岁，处方≥ 1 种抗风湿药物，无银屑病诊断，且有索引后记录。患者无心肌梗死/中风 ≤ 31 天（MACE 队列）或恶性肿瘤：在 MACE 组群（n = 16 012）和恶性肿瘤组群（n = 14 545）中，大多数患者为女性，年龄≥ 65 岁。总体而言，每 43964.7 患者年发生 214 例 MACE（发病率为每 100 患者年 0.49 例），每 40251.6 患者年发生 315 例恶性肿瘤（发病率为每 100 患者年 0.78 例）。男性、高龄（≥ 65 岁）、高血压、肾脏疾病、脑血管疾病和既往 X 光检查与 MACE 风险增加显著相关。男性性别、年龄较大（≥ 50 岁）、使用非甾体类抗炎药、肺气肿、严重感染、恶性肿瘤病史和既往接受过 X 光检查与恶性肿瘤风险的增加明显相关。相反，糖皮质激素的使用和骨折诊断与恶性肿瘤风险的降低明显相关：结论：在日本的RA患者中，男性、高龄和既往接受过X光检查与MACE和恶性肿瘤风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Risk Factors Associated With Major Adverse Cardiovascular Events and Malignancies in Patients With Rheumatoid Arthritis in a Real-World Setting in Japan

查看原文本刊更多论文

Risk Factors Associated With Major Adverse Cardiovascular Events and Malignancies in Patients With Rheumatoid Arthritis in a Real-World Setting in Japan

Aim

To identify risk factors associated with major adverse cardiovascular events (MACE) and malignancies in patients with rheumatoid arthritis (RA) using real-world data from Japan.

Methods

This cohort study used the Real World Data database of medical institutions in Japan. Eligible patients (January 2013–December 2021) had ≥ 1 RA diagnosis, were aged ≥ 18 years, prescribed ≥ 1 antirheumatic drug, had no psoriasis diagnosis, and had a record postindex. Patients had no myocardial infarction/stroke ≤ 31 days (MACE cohort) or malignancy < 1 year (malignancy cohort) before index. Cohorts were determined by incidence of initial MACE or malignancy. Known/exploratory variables were selected using Cox regression models.

Results

Across MACE (n = 16 012) and malignancy (n = 14 545) cohorts, most patients were female and aged ≥ 65 years. Overall, 214 MACE per 43964.7 patient-years (incidence rate 0.49 per 100 patient-years) and 315 malignancies per 40251.6 patient-years (incidence rate 0.78 per 100 patient-years) occurred. Male sex, older age (≥ 65 years), hypertension, renal disease, cerebrovascular disease, and prior X-ray examination were significantly associated with increased MACE risk. Male sex, older age (≥ 50 years), nonsteroidal anti-inflammatory drug use, emphysema, serious infection, malignancy history, and prior X-ray examination were significantly associated with increased malignancy risk. Conversely, glucocorticoid use and fracture diagnosis were significantly associated with reduced malignancy risk.

Conclusion

In patients with RA in Japan, male sex, older age, and prior X-ray examination were associated with increased MACE and malignancy risk.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.