局部莫匹罗星治疗减少干扰素和髓系信号在皮肤红斑狼疮病变通过靶向葡萄球菌种

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-12-08 DOI:10.1002/art.43079

Lisa Abernathy-Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Celine Berthier, Annie Lu, Zeran Zhang, Amy Hurst, Johann E. Gudjonsson, J. Michelle Kahlenberg

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引用次数: 0

摘要

皮肤红斑狼疮（CLE）是系统性红斑狼疮（SLE）的炎症性皮肤表现。I型干扰素（ifn）促进炎症反应，并在CLE病变中升高。我们最近报道了CLE病变经常被金黄色葡萄球菌（金黄色葡萄球菌）定植。在这里，我们在一项概念验证研究中进行了后续研究，以调查莫匹罗星（一种局部抗生素治疗金黄色葡萄球菌介导的皮肤感染）是否可以调节CLE病变中的I型IFN和炎症基因特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Topical mupirocin treatment reduces interferon and myeloid signatures in cutaneous lupus erythematous lesions through targeting of Staphylococcus species

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Topical mupirocin treatment reduces interferon and myeloid signatures in cutaneous lupus erythematous lesions through targeting of Staphylococcus species

Cutaneous lupus erythematosus (CLE) is an inflammatory skin manifestation of systemic lupus erythematosus (SLE). Type I interferons (IFNs) promote inflammatory responses and are elevated in CLE lesions. We recently reported that CLE lesions are frequently colonized with Staphylococcus aureus (S. aureus). Here, we follow up in a proof-of-concept study to investigate whether type I IFN and inflammatory gene signatures in CLE lesions can be modulated with mupirocin, a topical antibiotic treatment against S. aureus-mediated skin infections.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.