一种用于外部和内部光动力治疗的装置的建议和操作评估。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104440

Enrique Navarrete de Gálvez , Pablo Fonda Pascual , José Aguilera Arjona , José Ramón de Andrés Díaz , María Navarrete de Gálvez , Shiran Perera Mohamed , María Victoria de Gálvez Aranda

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引用次数: 0

摘要

光动力治疗（PDT）光源必须将其发射光谱与光敏剂的吸收光谱相匹配，提供精确的治疗定义，提供足够的辐照度以避免热损伤，并最大限度地缩短治疗时间。此外，它们应该适应不同的光敏剂，易于操作，并具有成本效益。目前的LED光源难以定制，刚性，主要用于广域处理。对于局部治疗，通常采用激光技术。我们提出了一种可定制和可编程的基于LED的设备，不仅满足这些规范，而且还解决了当前LED源在局部治疗方面的局限性。它允许连接用于内部治疗的光纤终端，并且可以安装能够从外部治疗病变或从内部穿透病变的光扩散装置。该设备是先前开发的光源的增强版本，该光源已在几项光动力治疗的试点研究中证明了有效性。拟议的设备在医疗和研究应用方面显示出巨大的潜力，能够根据需要配置发射光谱，并根据所治疗的病变类型建立量身定制的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments

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Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments

Photodynamic therapy (PDT) light sources must match their emission spectrum with the absorption spectrum of the photosensitizer, provide precise treatment definition, deliver adequate irradiance, avoid thermal damage, and minimize treatment duration. Additionally, they should be adaptable to different photosensitizers, easy to manipulate, and cost-effective.

Current LED sources are difficult to customize, rigid, and primarily designed for broad-area treatments. For localized treatments, laser technology is commonly employed.

We propose a customizable and programmable LED-based device that not only meets these specifications but also addresses the limitations of current LED sources for localized treatments. It allows for the connection of a fiber optic terminal for internal treatments and can be fitted with light-diffusing devices capable of treating lesions externally or penetrating them internally. This device is an enhanced version of a previously developed source that has demonstrated efficacy in several pilot studies of photodynamic therapy.

The proposed equipment shows significant potential for both medical and research applications, enabling the configuration of emission spectra on demand and the establishment of tailored treatment protocols based on the type of lesion being treated.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.