震颤的故事:非典型猪瘟病毒诱发先天性震颤猪的全身和神经症状队列研究。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
F H Aae, M Stokstad, M Myrmel, R Sørby, A Bergfeldt, B Ranheim
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引用次数: 0

摘要

由非典型猪瘟病毒(APPV)引起的先天性震颤(CT)是一种广泛存在于养猪业的疾病。它的特征是新生仔猪的震颤,但震颤的描述和与其他临床症状的关联并没有很好的文献记载。本研究的目的是表征appv诱导的CT的一般和神经学临床体征,并描述不同体征之间的进展和关联。进行了一项队列研究,包括37头来自经appv确诊CT窝的猪和27头来自健康窝的对照猪。所有猪从出生到屠宰进行了五次检查,包括一般和神经参数,以及详细的震颤特征。各种程度的震颤,从严重程度到没有震颤,都可以在窝中看到。震颤持续整个哺乳期,断奶期为60%,屠宰期为40%,与初始震颤程度无关(P=0.9)。震颤与意向震颤一致,随着猪年龄的增长,震颤通常从影响全身到较小的区域,频率增加,幅度减小。在哺乳期,震颤与高心率(P=0.0018)和宽体位(P=0.0198)相关。未观察到其他神经学症状或八字腿。严重震颤抑制自主运动,并与一般状况(P=0.0017)、下肢状况评分(P=0.0044)、更多的腕病变(P=0.0163)和关节炎(P=0.0198)相关。意向性震颤和心悸与小脑疾病相对应,尽管没有其他典型的症状。观察到的震颤和相关的临床表现似乎对动物福利有严重的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tremor tales: A cohort study of general and neurological signs in pigs with atypical porcine pestivirus-induced congenital tremor.

Congenital tremor (CT) caused by atypical porcine pestivirus (APPV) is a widespread disease in the swine industry. It is characterized by tremors in newborn piglets, but tremor description and association to other clinical signs are not well documented. This study's objectives were to characterize general and neurological clinical signs of APPV-induced CT and describe the progression and associations between the different signs. A cohort study was conducted including 37 pigs from litters with APPV-confirmed CT and 27 control pigs from healthy litters. All pigs were examined five times from birth to slaughter, including general and neurological parameters, and detailed tremor characterization. All levels of tremor, from grave severity to no tremor, were seen within litters. Tremor persisted throughout the suckling period for all, to weaner age for 60 % and to slaughter age for 40 %, unrelated to the initial degree of tremor (P = 0.9). Tremors were consistent with intention tremor and typically went from affecting the whole body to smaller regions as the pig aged, while frequency increased, and amplitude decreased. Tremor was associated with hypermetria (P = 0.0018) and a broad stance (P = 0.0198) during the suckling period. No other neurological signs, or splay leg, were observed. Severe tremor inhibited voluntary movement and was associated with reduced general condition (P = 0.0017), lower body condition score (P = 0.0044), more carpal lesions (P = 0.0163) and arthritis (P = 0.0198). Intention tremor and hypermetria corresponds to cerebellar diseases, although other typical signs of this were absent. Both the tremor observed, and the associated clinical manifestations appear to have severe animal welfare implications.

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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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