铜稳态和铜中毒：探索结缔组织疾病的新治疗策略。

IF 4.7 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-01-03 DOI:10.1016/j.intimp.2024.113698

Wenlan Zhang , Zhijie Song , Yuanyuan Tian , Ruifeng Zhang , Zhigang Guo , Yanmei Yang , Xijuan Jiang , Ruoyi Zhang

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引用次数: 0

摘要

铜是人类健康不可缺少的元素，其平衡对于预防疾病，特别是影响结缔组织的疾病的发病至关重要。铜水平不平衡可导致病理改变。研究表明，铜补充剂和螯合剂有望治疗某些疾病，但铜失衡和被称为铜中毒的细胞死亡机制导致结缔组织疾病的确切机制仍然难以捉摸。本文探讨了铜失衡和铜缺乏症在结缔组织疾病中的潜在作用，并对其潜在的细胞机制进行了评价。目标是为铜代谢失调的靶向治疗提供实用的见解，目的是为结缔组织疾病的治疗设计新的策略。

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Copper homeostasis and Cuprotosis: Exploring novel therapeutic strategies for connective tissue diseases

Copper is an indispensable element for human health, with its balance being critical to prevent the onset of diseases, particularly those affecting connective tissues. Imbalances in copper levels can lead to pathological alterations. Research indicates that copper supplements and chelators hold promise for the treatment of certain conditions, yet the precise mechanisms by which copper imbalances and the cell death mechanism known as cuprotosis contribute to connective tissue diseases remain elusive. This paper delves into the potential role of copper imbalance and cuprotosis in connective tissue diseases and evaluates the underlying cellular mechanisms. The goal is to offer practical insights into targeted therapies for dysregulated copper metabolism, with the aim of devising novel strategies for the treatment of connective tissue diseases.

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.