组蛋白H4K8hib修饰促进基因表达，调控水稻免疫。

IF 17.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Plant Pub Date : 2025-01-06 Epub Date: 2024-12-06 DOI:10.1016/j.molp.2024.12.003

Qiutao Xu, Xuan Ma, Xuelu Wei, Zhengting Chen, Yuhang Duan, Yuliang Ju, Zhaoyun Wang, Jing Chen, Lu Zheng, Xiaolin Chen, Junbin Huang, Jisen Zhang, Xiaoyang Chen

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引用次数: 0

摘要

摘要：本研究揭示了H4K8hib在水稻中作为一个活跃的表观遗传标记，与基因表达呈正相关，增强免疫应答。此外，HDA705被鉴定为调控H4K8hib的关键酶。HDA705突变导致hyper-H4K8hib，进而激活防御相关基因的表达，增强水稻对病原体的抗性。

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Histone H4K8hib modification promotes gene expression and regulates rice immunity.

This study uncovers the role of H4K8hib as an active epigenetic mark in rice that positively correlates with gene expression and enhances immune responses. Furthermore, HDA705 was identified as the key enzyme regulating H4K8hib. Mutation of HDA705 led to hyper-H4K8hib, which in turn activated the expression of defense-related genes and enhanced rice resistance to pathogens.

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来源期刊

Molecular Plant 植物科学-生化与分子生物学

CiteScore

37.60

自引率

2.20%

发文量

1784

审稿时长

1 months

期刊介绍： Molecular Plant is dedicated to serving the plant science community by publishing novel and exciting findings with high significance in plant biology. The journal focuses broadly on cellular biology, physiology, biochemistry, molecular biology, genetics, development, plant-microbe interaction, genomics, bioinformatics, and molecular evolution. Molecular Plant publishes original research articles, reviews, Correspondence, and Spotlights on the most important developments in plant biology.